Influences of simulated gastrointestinal environment on physicochemical properties of gold nanoparticles and their implications on intestinal epithelial permeability.

Q2 Biochemistry, Genetics and Molecular Biology

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2019-01-01 Epub Date: 2019-06-22 DOI:10.1080/10590501.2019.1602994

Xiumei Jiang, Xiaowei Zhang, Patrick Gray, Jiwen Zheng, Timothy R Croley, Peter P Fu, Jun-Jie Yin

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引用次数: 7

Abstract

Gold nanoparticles (Au NPs) hold great promise in food, industrial and biomedical applications due to their unique physicochemical properties. However, influences of the gastrointestinal tract (GIT), a likely route for Au NPs administration, on the physicochemical properties of Au NPs has been rarely evaluated. Here, we investigated the influence of GIT fluids on the physicochemical properties of Au NPs (5, 50, and 100 nm) and their implications on intestinal epithelial permeability in vitro. Au NPs aggregated in fasted gastric fluids and generated hydroxyl radicals in the presence of H₂O₂. Cell studies showed that GIT fluids incubation of Au NPs affected the cellular uptake of Au NPs but did not induce cytotoxicity or disturb the intestinal epithelial permeability.

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模拟胃肠环境对金纳米颗粒理化性质的影响及其对肠上皮通透性的影响。

金纳米颗粒(Au NPs)由于其独特的物理化学性质，在食品、工业和生物医学应用中具有很大的前景。然而，作为Au NPs可能的给药途径，胃肠道(GIT)对Au NPs理化性质的影响很少被评估。在此，我们研究了GIT液体对Au NPs(5、50和100 nm)理化性质的影响及其对体外肠上皮通透性的影响。Au NPs在空腹胃液中聚集，并在H2O2存在下产生羟基自由基。细胞研究表明，金NPs的GIT液孵育影响了金NPs的细胞摄取，但不诱导细胞毒性或扰乱肠上皮的通透性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews 环境科学-毒理学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews aims at rapid publication of reviews on important subjects in various areas of environmental toxicology, health and carcinogenesis. Among the subjects covered are risk assessments of chemicals including nanomaterials and physical agents of environmental significance, harmful organisms found in the environment and toxic agents they produce, and food and drugs as environmental factors. It includes basic research, methodology, host susceptibility, mechanistic studies, theoretical modeling, environmental and geotechnical engineering, and environmental protection. Submission to this journal is primarily on an invitational basis. All submissions should be made through the Editorial Manager site, and are subject to peer review by independent, anonymous expert referees. Please review the instructions for authors for manuscript submission guidance.