{"title":"Serum Chemerin Levels Correlate With Determinants of Metabolic Syndrome in Obese Children and Adolescents.","authors":"Hong-Jun Ba, Ling-Ling Xu, You-Zhen Qin, Hong-Shan Chen","doi":"10.1177/1179556519853780","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate serum chemerin concentrations in obese children and adolescents and to investigate the associations of chemerin with body mass index (BMI), lipid levels, and insulin sensitivity.</p><p><strong>Methods: </strong>Forty-eight obese and 40 nonobese Chinese children and adolescents were included in the study. BMI and levels of chemerin, lipids, glucose, and insulin were measured following an overnight fast. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and BMI standard deviation score (BMI-SDS) were determined for all participants.</p><p><strong>Results: </strong>Serum chemerin levels were found to be significantly higher in obese children and adolescents than in control group members (94.83 ± 5.99 ng/mL vs 56.43 ± 4.16 ng/mL, <i>P</i> < .001). There were significant correlations between chemerin and age, BMI, BMI-SDS, total triglyceride (TG) levels, insulin levels, and HOMA-IR. After controlling for age, we found that chemerin levels were also significantly correlated with BMI-SDS (r =+ 0.284, <i>P</i> = .008) and HOMA-IR (r =+ 0.241, <i>P</i> = .034). In a stepwise multiple regression analysis, we observed only BMI-SDS to be an important determinant of chemerin level.</p><p><strong>Conclusions: </strong>In our sample of Chinese children and adolescents, chemerin levels were significantly higher in the obese group than in the control group. Chemerin levels were positively correlated with BMI-SDS and HOMA-IR and negatively correlated with age. We thus believe that further study is necessary to investigate the risk of metabolic abnormalities in young obese children and adolescents.</p>","PeriodicalId":45027,"journal":{"name":"Clinical Medicine Insights-Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2019-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179556519853780","citationCount":"26","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Medicine Insights-Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1179556519853780","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 26
Abstract
Objectives: This study aimed to investigate serum chemerin concentrations in obese children and adolescents and to investigate the associations of chemerin with body mass index (BMI), lipid levels, and insulin sensitivity.
Methods: Forty-eight obese and 40 nonobese Chinese children and adolescents were included in the study. BMI and levels of chemerin, lipids, glucose, and insulin were measured following an overnight fast. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and BMI standard deviation score (BMI-SDS) were determined for all participants.
Results: Serum chemerin levels were found to be significantly higher in obese children and adolescents than in control group members (94.83 ± 5.99 ng/mL vs 56.43 ± 4.16 ng/mL, P < .001). There were significant correlations between chemerin and age, BMI, BMI-SDS, total triglyceride (TG) levels, insulin levels, and HOMA-IR. After controlling for age, we found that chemerin levels were also significantly correlated with BMI-SDS (r =+ 0.284, P = .008) and HOMA-IR (r =+ 0.241, P = .034). In a stepwise multiple regression analysis, we observed only BMI-SDS to be an important determinant of chemerin level.
Conclusions: In our sample of Chinese children and adolescents, chemerin levels were significantly higher in the obese group than in the control group. Chemerin levels were positively correlated with BMI-SDS and HOMA-IR and negatively correlated with age. We thus believe that further study is necessary to investigate the risk of metabolic abnormalities in young obese children and adolescents.
目的:本研究旨在调查肥胖儿童和青少年的血清趋化素浓度,并探讨趋化素与体重指数(BMI)、脂质水平和胰岛素敏感性的关系。方法:将48名肥胖儿童和40名非肥胖儿童和青少年纳入研究。在禁食一夜之后,测量了BMI和趋化素、血脂、葡萄糖和胰岛素的水平。测定所有参与者的胰岛素抵抗稳态模型评估(HOMA-IR)和BMI标准偏差评分(BMI- sds)。结果:肥胖儿童和青少年血清趋化素水平明显高于对照组(94.83±5.99 ng/mL vs 56.43±4.16 ng/mL, P P = 0.008)和HOMA-IR (r =+ 0.241, P = 0.034)。在逐步多元回归分析中,我们观察到只有BMI-SDS是趋化素水平的重要决定因素。结论:在我们的中国儿童和青少年样本中,肥胖组的趋化素水平明显高于对照组。Chemerin水平与BMI-SDS、HOMA-IR呈正相关,与年龄负相关。因此,我们认为有必要进一步研究年轻肥胖儿童和青少年代谢异常的风险。