The Relation Between Periodontal Disease and Vitamin D.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-03-01

Colin Bonnet, Rasheda Rabbani, Michael E K Moffatt, Anastasia Kelekis-Cholakis, Robert J Schroth

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引用次数: 0

Abstract

Background: There is conflicting evidence regarding the association between vitamin D and periodontal disease. The purpose of this study was to explore that relation.

Methods: This cross-sectional study used data from the Canadian Health Measures Survey for respondents 13-79 years of age. Vitamin D status was determined by measuring plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Periodontal disease was defined by gingival index (GI) and calculated loss of attachment (LOA). Statistical analyses included bivariate tests and multiple logistic regression.

Results: At the bivariate level, 25(OH)D concentrations below the cutoff levels of 50 nmol/L and 75 nmol/L were associated with GI. However, multiple regression analyses for GI revealed no association with mean 25(OH)D level or either concentration. Although no significant association between LOA and 25(OH)D status was identified at the bivariate level, a statistically significant association was observed between LOA and 25(OH)D levels < 75 nmol/L on multiple regression analysis. However, mean 25(OH)D concentrations and those < 50 nmol/L were not associated with LOA on multiple regression analysis.

Conclusion: Vitamin D status was inversely associated with GI at the bivariate level, but not at the multivariate level. Conversely, vitamin D status was not associated with LOA at the bivariate level, but it was inversely associated with LOA at the multivariate level. These results provide modest evidence supporting a relation between low plasma 25(OH)D concentrations and periodontal disease as measured by GI and LOA.

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牙周病与维生素D的关系

背景:关于维生素D和牙周病之间的关系，有相互矛盾的证据。本研究的目的是探讨这种关系。方法:这项横断面研究使用加拿大健康措施调查的数据，调查对象为13-79岁的受访者。通过测定血浆25-羟基维生素D (25(OH)D)浓度来确定维生素D状态。通过牙龈指数(GI)和计算的附着损失(LOA)来定义牙周病。统计分析包括双变量检验和多元逻辑回归。结果:在双变量水平上，低于50 nmol/L和75 nmol/L的25(OH)D浓度与GI相关。然而，GI的多元回归分析显示与平均25(OH)D水平或浓度无关。虽然在双变量水平上没有发现LOA与25(OH)D水平之间的显著关联，但在多元回归分析中，LOA与25(OH)D水平< 75 nmol/L之间存在统计学上显著的关联。但经多元回归分析，平均25(OH)D浓度和< 50 nmol/L与LOA无相关性。结论:维生素D水平在双变量水平上与GI呈负相关，而在多变量水平上不呈负相关。相反，维生素D水平在双变量水平上与LOA无关，但在多变量水平上与LOA呈负相关。这些结果提供了适度的证据，支持低血浆25(OH)D浓度与GI和LOA测量的牙周病之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.