Mechanobiology of Cancer Stem Cells and Their Niche.

Q2 Medicine

Cancer Microenvironment Pub Date : 2019-04-01 Epub Date: 2019-04-19 DOI:10.1007/s12307-019-00222-4

Ankit Roy Choudhury, Surabhi Gupta, Pradeep Kumar Chaturvedi, Neeraj Kumar, Deepak Pandey

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引用次数: 0

Abstract

Though the existence of cancer stem cells remained enigmatic initially, over the time their participation in tumorigenesis and tumor progression has become highly evident. Today, they are also appreciated as the causal element for tumor heterogeneity and drug-resistance. Cancer stem cells activate a set of molecular pathways some of which are triggered by the unique mechanical properties of the tumor tissue stroma. A relatively new field called mechanobiology has emerged, which aims to critically evaluate the mechanical properties associated with biological events like tissue morphogenesis, cell-cell or cell-matrix interactions, cellular migration and also the development and progression of cancer. Development of more realistic model systems and biophysical instrumentation for observation and manipulation of cell-dynamics in real-time has invoked a hope for some novel therapeutic modalities against cancer in the future. This review discusses the fundamental concepts of cancer stem cells from an intriguing viewpoint of mechanobiology and some important breakthroughs to date.

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癌症干细胞及其龛位的机制生物学。

尽管癌症干细胞的存在最初仍是个谜，但随着时间的推移，它们在肿瘤发生和发展过程中的参与已变得非常明显。如今，它们还被认为是肿瘤异质性和耐药性的诱因。癌症干细胞激活了一系列分子途径，其中一些是由肿瘤组织基质独特的机械特性引发的。机械生物学是一个相对较新的领域，旨在批判性地评估与组织形态发生、细胞-细胞或细胞-基质相互作用、细胞迁移以及癌症发展和进展等生物事件相关的机械特性。开发更逼真的模型系统和生物物理仪器，用于实时观察和操纵细胞动力学，为未来一些新型的癌症治疗方法带来了希望。本综述从机械生物学的角度探讨癌症干细胞的基本概念，以及迄今为止取得的一些重要突破。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Microenvironment Medicine-Oncology

CiteScore

4.90

自引率

0.00%

发文量

期刊介绍： Cancer Microenvironment is the official journal of the International Cancer Microenvironment Society (ICMS). It publishes original studies in all aspects of basic, clinical and translational research devoted to the study of cancer microenvironment. It also features reports on clinical trials. Coverage in Cancer Microenvironment includes: regulation of gene expression in the cancer microenvironment; innate and adaptive immunity in the cancer microenvironment, inflammation and cancer; tumor-associated stroma and extracellular matrix, tumor-endothelium interactions (angiogenesis, extravasation), cancer stem cells, the metastatic niche, targeting the tumor microenvironment: preclinical and clinical trials.