Therese Sterner, Ada Uldahl, Åke Svensson, Magnus P Borres, Sigrid Sjölander, Alf Tunsäter, Jonas Björk, Cecilia Svedman, Magnus Bruze, Laura von Kobyletzki, Hampus Kiotseridis
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引用次数: 13
Abstract
Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms.
Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing.
Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p < 0.001) and eczema (p < 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins.
Conclusion: The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.
背景:在IgE致敏与过敏、喘息、湿疹和食物过敏之间存在强烈和一致的联系。这些情况也存在于未致敏的人群中,而致敏也存在于没有过敏相关疾病的个体中。本研究的目的是分析人群中代表性样本的致敏概况,并将过敏原和过敏原成分的模式与过敏症状联系起来。方法:195名青少年参与了这项临床研究,包括自我报告问卷和体外IgE检测。结果:空气过敏原致敏比食物过敏原致敏更常见,分别为43%和14%。结论:本研究中来自瑞典正常人群的青少年主要对草花粉敏感,很少对特定的食物过敏原敏感。主要致敏物为草花粉原php1,其次为cyd1和php2。报告任何过敏症状的61%被致敏,与喘息和鼻结膜炎相关的过敏原成分为Fel d 4, Der f 2和Can f 5。
期刊介绍:
Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.