Significance Tests for Boosted Location and Scale Models with Linear Base-Learners.

IF 1.2 4区 数学 Q4 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Tobias Hepp, Matthias Schmid, Andreas Mayr
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引用次数: 8

Abstract

Generalized additive models for location scale and shape (GAMLSS) offer very flexible solutions to a wide range of statistical analysis problems, but can be challenging in terms of proper model specification. This complex task can be simplified using regularization techniques such as gradient boosting algorithms, but the estimates derived from such models are shrunken towards zero and it is consequently not straightforward to calculate proper confidence intervals or test statistics. In this article, we propose two strategies to obtain p-values for linear effect estimates for Gaussian location and scale models based on permutation tests and a parametric bootstrap approach. These procedures can provide a solution for one of the remaining problems in the application of gradient boosting algorithms for distributional regression in biostatistical data analyses. Results from extensive simulations indicate that in low-dimensional data both suggested approaches are able to hold the type-I error threshold and provide reasonable test power comparable to the Wald-type test for maximum likelihood inference. In high-dimensional data, when gradient boosting is the only feasible inference for this model class, the power decreases but the type-I error is still under control. In addition, we demonstrate the application of both tests in an epidemiological study to analyse the impact of physical exercise on both average and the stability of the lung function of elderly people in Germany.

基于线性基础学习器的提升位置和比例模型的显著性检验。
位置尺度和形状的广义加性模型(GAMLSS)为广泛的统计分析问题提供了非常灵活的解决方案,但在适当的模型规范方面可能具有挑战性。这个复杂的任务可以使用正则化技术(如梯度增强算法)来简化,但是从这些模型中得到的估计会缩小到零,因此计算适当的置信区间或测试统计量并不简单。在本文中,我们提出了基于置换检验和参数自举方法的两种策略来获得高斯位置和比例模型的线性效应估计的p值。这些程序可以为在生物统计数据分析中应用梯度增强算法进行分布回归的遗留问题之一提供解决方案。大量的模拟结果表明,在低维数据中,这两种方法都能够保持i型误差阈值,并提供与最大似然推断的wald型测试相当的合理测试功率。在高维数据中,当梯度增强是该模型类唯一可行的推理时,功率降低,但i型误差仍在控制范围内。此外,我们在流行病学研究中展示了这两种测试的应用,以分析体育锻炼对德国老年人肺功能的平均和稳定性的影响。
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来源期刊
International Journal of Biostatistics
International Journal of Biostatistics MATHEMATICAL & COMPUTATIONAL BIOLOGY-STATISTICS & PROBABILITY
CiteScore
2.10
自引率
8.30%
发文量
28
审稿时长
>12 weeks
期刊介绍: The International Journal of Biostatistics (IJB) seeks to publish new biostatistical models and methods, new statistical theory, as well as original applications of statistical methods, for important practical problems arising from the biological, medical, public health, and agricultural sciences with an emphasis on semiparametric methods. Given many alternatives to publish exist within biostatistics, IJB offers a place to publish for research in biostatistics focusing on modern methods, often based on machine-learning and other data-adaptive methodologies, as well as providing a unique reading experience that compels the author to be explicit about the statistical inference problem addressed by the paper. IJB is intended that the journal cover the entire range of biostatistics, from theoretical advances to relevant and sensible translations of a practical problem into a statistical framework. Electronic publication also allows for data and software code to be appended, and opens the door for reproducible research allowing readers to easily replicate analyses described in a paper. Both original research and review articles will be warmly received, as will articles applying sound statistical methods to practical problems.
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