Signaling pathways in cerebellar granule cells development.

Abstract

Cerebellar granule cells originate from precursors located at the dorsal region of rhombomere in the hindbrain of embryos. They undergo proliferation from embryo to post-natal period so as to form the major cell type of the cerebellum. The development of granule cell is not only highly dependent on the cerebellar intrinsic environment, but also is regulated by serials of transcription factors on different signaling pathways. Therefore, in this manuscript the signaling pathways participating in the proliferation and differentiation of granular cells during normal development was reviewed.