Chemistry and Biology of Selected Mexican Medicinal Plants.

Q1 Medicine
Rachel Mata, Mario Figueroa, Andrés Navarrete, Isabel Rivero-Cruz
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引用次数: 18

Abstract

Herbal medicines are an integral element of alternative medical care in Mexico, and the best testimony to their efficacy and cultural value is their persistence in contemporary Mexican marketplaces where the highest percentages of medicinal and aromatic plants are sold. This chapter summarizes current trends in research on medicinal plants in Mexico, with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described.From this contribution, it is evident that in the last five decades a significant amount of research on medicinal plants has been performed by Mexican scientists. Such efforts have led to the publication of many research papers in noted peer-reviewed journals and technical books. The isolation and structural characterization of hundreds of bioactive secondary metabolites have been accomplished, and most importantly, these studies have tended to support the ethnomedical uses of many different species. A multidisciplinary approach for investigating these plants has led to an increased emphasis on areas such as phytopharmacology, phytotoxicology, quality control, regulation, and conservation issues for these valuable resources. The medicinal plants analyzed so far have shown a very broad chemical diversity of their constituents, which have a high potential for exhibiting novel mechanistic effects biologically. The chapter shows also that there is need to conduct additional clinical studies on herbal drugs, in particular because the longstanding traditional evidence for their safety is not always sufficient to assure their rational use. There is also need to move to "omics" approaches for investigating the holistic effect and the influence of groups of phytochemicals on the whole organism. Mexican scientists may be expected to have bright prospects in this regard, which will imbue medicinal plant research with a new dynamism in the future.

墨西哥药用植物的化学和生物学。
草药是墨西哥替代医疗保健的一个组成部分,其功效和文化价值的最佳证明是它们在当代墨西哥市场上的持续存在,在这些市场上出售的药用和芳香植物的比例最高。本章总结了墨西哥药用植物研究的当前趋势,重点介绍了作者实验室开展的工作。最相关的植物化学和药理学概况的一组选定的植物广泛用于治疗主要的国家卫生问题描述。从这一贡献可以明显看出,在过去五十年中,墨西哥科学家对药用植物进行了大量的研究。这样的努力导致许多研究论文在著名的同行评审期刊和技术书籍上发表。数百种生物活性次生代谢物的分离和结构表征已经完成,最重要的是,这些研究倾向于支持许多不同物种的民族医学用途。研究这些植物的多学科方法导致越来越重视诸如植物药理学,植物毒理学,质量控制,法规和保护这些宝贵资源的问题。到目前为止,已分析的药用植物已显示出其成分的广泛化学多样性,这有很大的潜力显示出新的生物学机制作用。本章还表明,有必要对草药进行额外的临床研究,特别是因为长期以来的传统证据证明其安全性并不总是足以确保其合理使用。还需要转向“组学”方法,以研究植物化学物质组对整个生物体的整体效应和影响。墨西哥科学家在这方面可能会有光明的前景,这将在未来为药用植物研究注入新的活力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
4.40
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