Amyloid A in Serum and Ascitic Fluid as a Novel Diagnostic Marker of Spontaneous Bacterial Peritonitis.

Q2 Medicine

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2020-01-01 DOI:10.2174/1871523018666190401154447

Rehab Badawi, Muhammad N Asghar, Sherief Abd-Elsalam, Samah A Elshweikh, Tamer Haydara, Sherein M Alnabawy, Mahmoud Elkadeem, Walaa ElKhalawany, Samah Soliman, Reham Elkhouly, Shimaa Soliman, Mona Watany, Mai Khalif, Asem Elfert

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引用次数: 5

Abstract

Background: Diagnosis of Spontaneous Bacterial Peritonitis (SBP) depends mainly on ascetic fluid culture which may be negative in spite of the clinical suggestion of SBP and high ascetic fluid neutrophilic count.

Aims: This study aimed to evaluate the biological importance of amyloid A biomarker in both serum and ascetic fluid to diagnose SBP as early as possible and to compare it to other markers (C-reactive protein (CRP), and the neutrophil-to-lymphocyte ratio (NLR)).

Methods: This study included 37 patients with hepatic ascites; twenty-two of them had SBP, and 15 patients did not have SBP. Serum and ascetic fluid amyloid A, ascetic fluid neutrophil, C-reactive protein, and neutrophil-to-lymphocyte ratio were measured in all subjects before the start of antimicrobial chemotherapy to the infected ones.

Results: Both the serum and ascetic fluid amyloid and also, CRP were significantly higher in patients infected with ascetic fluid than others. The cut-off point of serum amyloid A for early detection of SBP was 9.25ug/ml with the high sensitivity and specificity. For ascetic amyloid A, the sensitivity and specificity were 90.09% and 60% at cut-off point 2.85ug/ml, respectively.

Conclusion: Amyloid A in serum and ascitic fluid can be considered as a good biomarker for early diagnosis of SBP.

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血清和腹水淀粉样蛋白A作为自发性细菌性腹膜炎的新诊断标志物。

背景:自发性细菌性腹膜炎(SBP)的诊断主要依赖于禁欲液培养，尽管临床提示SBP和高禁欲液中性粒细胞计数，但可能呈阴性。目的:本研究旨在评估血清和禁欲液中淀粉样蛋白A生物标志物对早期诊断收缩压的生物学意义，并将其与其他标志物(c反应蛋白(CRP)和中性粒细胞与淋巴细胞比值(NLR))进行比较。方法:本研究纳入肝性腹水患者37例;22例有收缩压，15例无收缩压。在开始对感染者进行抗菌化疗前，测定所有受试者血清和苦行液淀粉样蛋白A、苦行液中性粒细胞、c反应蛋白和中性粒细胞与淋巴细胞的比值。结果:苦行液感染患者血清、苦行液淀粉样蛋白及CRP均明显高于其他患者。血清淀粉样蛋白A早期检测收缩压的截止点为9.25ug/ml，具有较高的敏感性和特异性。对于苦行性淀粉样蛋白A，在截断点2.85ug/ml时，敏感性为90.09%，特异性为60%。结论:血清和腹水淀粉样蛋白A可作为早期诊断收缩压的良好生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.