Stereotactic Radiosurgery for Low-Grade Gliomas.

Q2 Medicine

Progress in neurological surgery Pub Date : 2019-01-01 Epub Date: 2019-05-16 DOI:10.1159/000493063

Ajay Niranjan, Andrew Faramand, L Dade Lunsford

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引用次数: 6

Abstract

Low-grade gliomas represent a heterogeneous group of tumors. The goals of treatment include prolonged survival and reduced morbidity. Treatment strategies vary depending upon tumor histology, anatomic location, age, and the general medical condition of the patient. Safe surgical resection remains the first choice for the treatment of resectable tumors. In cases of unresectable lesions, adjuvant radiotherapy and chemotherapy are considered. Several reports in recent years have documented the safety and effectiveness of stereotactic radiosurgery (SRS) in controlling tumor growth and improving patients' survival for patients with low-grade gliomas. Patients with progressive, pilocytic, or grade 2 fibrillary astrocytomas, located in critical or deep areas of the brain, are ideal candidates for radiosurgery. The use of SRS as part of multimodal therapy for progressive, recurrent, or unresectable pilocytic or WHO grade 2 fibrillary astrocytomas is a safe and promising therapeutic modality. Gamma Knife radiosurgery has progressively gained more relevance in the management of low-grade gliomas.

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立体定向放射外科治疗低级别胶质瘤。

低级别胶质瘤是一类异质性的肿瘤。治疗的目标包括延长生存期和降低发病率。治疗策略因肿瘤组织学、解剖位置、年龄和患者的一般医疗状况而异。安全手术切除仍然是治疗可切除肿瘤的首选。对于无法切除的病变，可以考虑辅助放疗和化疗。近年来的一些报道证明了立体定向放射手术(SRS)在控制肿瘤生长和提高低级别胶质瘤患者生存率方面的安全性和有效性。进行性、毛细胞性或2级纤维星形细胞瘤患者，位于大脑的关键或深部区域，是放射手术的理想候选者。使用SRS作为进行性、复发性或不可切除的毛细胞性或WHO 2级纤维星形细胞瘤的多模式治疗的一部分是一种安全且有前景的治疗方式。伽玛刀放射外科在低级别胶质瘤的治疗中逐渐获得了更多的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in neurological surgery Medicine-Surgery

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期刊介绍： Published since 1966, this series has become universally recognized as the most significant group of books serving neurological surgeons. Volumes feature contributions from distinguished international surgeons, who brilliantly review the literature from the perspective of their own personal experience. The result is a series of works providing critical distillations of developments of central importance to the theory and practice of neurological surgery.