The relationship between the apolipoprotein E e4 allele and hippocampal magnetic resonance imaging volume in community-dwelling individuals with mild Alzheimer's disease.

Degenerative Neurological and Neuromuscular Disease Pub Date : 2013-03-02 eCollection Date: 2013-01-01 DOI:10.2147/DNND.S40835

Bernard Walsh, Stuart Slater, Balakrishnan Nair, John Attia

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引用次数: 1

Abstract

Background: The degree of hippocampal magnetic resonance imaging (MRI) volume loss in Alzheimer's disease (AD) is commonly accepted as a marker of disease severity, yet remains expensive, unavailable, or not tolerated by many patients.

Aim: To examine whether the presence of one or more apolipoprotein E (ApoE) e4 alleles is associated with smaller hippocampal MRI volumes in a population of early AD patients.

Methods: A total of 88 consecutive patients attending a community-based memory disorders clinic who had both mild dementia on the Clinical Dementia Rating scale and Diagnostic and Statistical Manual of Mental Disorders criteria for probable AD were recruited. We examined the relationship between ApoE e4 allele load and hippocampal atrophy on MRI volumes.

Results: There was no association between the ApoE e4 load and hippocampal volume in this cohort.

Conclusion: This study suggests that the presence of one or more ApoE e4 alleles cannot be used to estimate pathological disease load in early AD.

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社区居民轻度阿尔茨海默病患者载脂蛋白ee4等位基因与海马磁共振成像体积的关系

背景:阿尔茨海默病(AD)的海马磁共振成像(MRI)体积损失程度通常被认为是疾病严重程度的标志，但仍然昂贵、不可用或许多患者不耐受。目的:研究一种或多种载脂蛋白E (ApoE) e4等位基因的存在是否与早期AD患者海马MRI体积较小有关。方法:共招募88名连续在社区记忆障碍诊所就诊的患者，这些患者在临床痴呆评定量表和可能AD的精神障碍诊断与统计手册标准中均患有轻度痴呆。我们在MRI体积上检查了apoee4等位基因负载与海马萎缩之间的关系。结果:在该队列中，ApoE e4载量与海马体积之间没有相关性。结论:本研究提示，一个或多个ApoE e4等位基因的存在不能用于估计早期AD的病理疾病负荷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Degenerative Neurological and Neuromuscular Disease

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