Genetic Tumor Syndromes with Endocrine Involvement: A Compendium and an Update.

4区 医学 Q2 Medicine
Yevgeniya Kushchayeva, Marissa Lightbourne, Maya Lodish, Constantine A Stratakis
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引用次数: 0

Abstract

Many hereditary and sporadic tumor and other syndromes are associated with endocrine functional and or structural abnormalities. The last few decades have yielded advancements in the field with improvements in diagnostic testing, screening guidelines and novel treatment options. In general, endocrine functional abnormalities and neoplasms share an early age of onset. There remains room for improvement as limited literature exists regarding clinical course, prognosis, and screening for earlier cancer detection. This should allow for more timely intervention, and possibly improved outcomes. The aim of this article is to summarize the current knowledge about prevalence, clinical course, and prognosis of functional and structural pituitary, thyroid, adrenal, and gonadal abnormalities in patients with 17 known syndromic, mostly tumor-predisposing, diseases, wherever possible, we review screening recommendations.

与内分泌累及的遗传肿瘤综合征:纲目和更新。
许多遗传性和散发性肿瘤和其他综合征与内分泌功能和/或结构异常有关。在过去的几十年里,随着诊断测试、筛查指南和新的治疗方案的改进,该领域取得了进展。一般来说,内分泌功能异常和肿瘤有一个共同的早期发病年龄。由于有关临床病程、预后和早期癌症检测筛查的文献有限,仍有改进的余地。这应该允许更及时的干预,并可能改善结果。本文的目的是总结目前关于17种已知综合征(主要是肿瘤易感性疾病)患者的功能性和结构性垂体、甲状腺、肾上腺和性腺异常的患病率、临床病程和预后的知识,并在可能的情况下回顾筛查建议。
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来源期刊
Pediatric endocrinology reviews : PER
Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism
自引率
0.00%
发文量
1
期刊介绍: PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.
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