The Incidence of Cytomegalovirus Glycoprotein B Genotypes in Kidney Transplant Recipients in Iran.

IF 0.3 Q4 TRANSPLANTATION

International Journal of Organ Transplantation Medicine Pub Date : 2018-01-01 Epub Date: 2018-11-01

A R Soleimani, M Jafari, A Piroozmand, H Nikoueinejad, H Akbari, B Einollahi

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引用次数: 0

Abstract

Background: Cytomegalovirus (CMV) is the most common opportunistic viral infection in kidney transplant recipients. CMV classification is usually based on its glycoprotein B (gB) genotypes, which divides the virus into 4 strains (gB1-4).

Objective: To determine the incidence of CMV genotypes in Iran and their relation to various clinical factors.

Methods: We studied 80 renal transplant recipients admitted to our transplant referral center between 2014 and 2015. All of the studied patients were monitored every 1-2 weeks for CMV infection by immunofluorescence method. There were 34 CMV-infected patients whose sera were studied with sequencing technique to identify the 4 CMV genotypes. All patients were followed up to 6 months after transplantation.

Results: gB1 was the most common genotype (35.3%); it was followed by gB3 and gB4 (each with 17.6 %), gB2, and mixed gB1,3 and gB1,2 (each with 14.7%). Age (p=0.037), time of infection after transplantation (p=0.011), and biopsy-proven rejection (p=0.012) were associated with CMV genotype. After adjusting for covariates, significant associations were found between genotype gB1 and family relationship (p=0.047) as well as HLA mismatch (p=0.014); genotype gB3 and family relationship (p=0.011); and genotype gB4 and age (p=0.019).

Conclusion: The most common CMV gB genotype in CMV-infected kidney transplant recipients in Iran was gB1. We recommend considering related therapeutic applications in the management of such patients.

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伊朗肾移植受者巨细胞病毒糖蛋白B基因型的发病率

背景:巨细胞病毒(CMV)是肾移植受者最常见的机会性病毒感染。CMV的分类通常基于其糖蛋白B (gB)基因型，将病毒分为4个毒株(gB1-4)。目的:了解伊朗地区巨细胞病毒基因型的发病率及其与各种临床因素的关系。方法:对2014 - 2015年间我院移植转诊中心收治的80例肾移植受者进行研究。采用免疫荧光法每1-2周监测患者巨细胞病毒感染情况。对34例CMV感染患者的血清进行测序，鉴定出4种CMV基因型。所有患者随访至移植后6个月。结果:gB1基因型最多见，占35.3%;其次是gB3和gB4(各占17.6%)，gB2和混合gb1,3和gb1,2(各占14.7%)。年龄(p=0.037)、移植后感染时间(p=0.011)和活检证实的排斥反应(p=0.012)与CMV基因型相关。校正协变量后，发现gB1基因型与家庭关系(p=0.047)和HLA错配(p=0.014)存在显著相关;基因型gB3与家族关系(p=0.011);基因型gB4与年龄的关系(p=0.019)。结论:伊朗CMV感染肾移植受者中最常见的CMV gB基因型为gB1。我们建议在此类患者的管理中考虑相关的治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Organ Transplantation Medicine TRANSPLANTATION-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.