Measuring Clonal Evolution in Cancer with Genomics.

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY
Marc J Williams, Andrea Sottoriva, Trevor A Graham
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引用次数: 47

Abstract

Cancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal cell number. Viewed through the lens of evolutionary biology, the transformation of normal cells into malignant cells is evolution in action. Evolution continues throughout cancer growth, progression, treatment resistance, and disease relapse, driven by adaptation to changes in the cancer's environment, and intratumor heterogeneity is an inevitable consequence of this evolutionary process. Genomics provides a powerful means to characterize tumor evolution, enabling quantitative measurement of evolving clones across space and time. In this review, we discuss concepts and approaches to quantify and measure this evolutionary process in cancer using genomics.

用基因组学测量癌症克隆进化。
癌症起源于人体内积累了遗传变异的体细胞。这些突变改变了细胞的表型,使它们能够摆脱维持正常细胞数量的稳态调节。从进化生物学的角度来看,正常细胞向恶性细胞的转化是进化的过程。在适应癌症环境变化的驱动下,进化在整个癌症生长、进展、治疗抵抗和疾病复发过程中持续进行,肿瘤内异质性是这一进化过程的不可避免的结果。基因组学提供了表征肿瘤进化的有力手段,使进化克隆的定量测量跨越空间和时间。在这篇综述中,我们讨论了概念和方法来量化和测量癌症基因组学的这一进化过程。
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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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