Stereotactic body radiation therapy in early-stage NSCLC: historical review, contemporary evidence and future implications.

Pub Date : 2019-02-27 eCollection Date: 2019-02-01 DOI:10.2217/lmt-2018-0013
Stephen Abel, Shaakir Hasan, Zachary D Horne, Athanasios Colonias, Rodney E Wegner
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Abstract

Clinical use of stereotactic body radiation therapy (SBRT) has increased dramatically over the last 2 decades and is the current standard-of-care in cases of inoperable early stage non-small-cell lung cancer. While surgical resection remains the standard-of-care for operable patients, several ongoing clinical trials are investigating the role of SBRT in these operative candidates as well. Taking into consideration the expanding role and utility of SBRT, this paper will: review the historical basis of SBRT; examine landmark trials establishing the framework for the current body of evidence; discuss areas of active and future research; and identify epidemiological trends that are likely to further increase the use of SBRT.

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早期NSCLC的立体定向身体放射治疗:历史回顾、当代证据和未来意义。
立体定向身体放射治疗(SBRT)的临床应用在过去20年中急剧增加,是目前无法手术的早期非小细胞肺癌癌症患者的治疗标准。虽然手术切除仍然是可手术患者的标准护理,但一些正在进行的临床试验也在调查SBRT在这些候选手术中的作用。考虑到SBRT的扩展作用和效用,本文将:回顾SBRT的历史基础;审查为现有证据体系建立框架的具有里程碑意义的审判;讨论当前和未来的研究领域;并确定可能进一步增加SBRT使用的流行病学趋势。
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