PPARδ, a Potential Therapeutic Target for Heart Disease.

Nuclear Receptor Research Pub Date : 2018-01-01 Epub Date: 2018-10-30 DOI:10.32527/2018/101375

Qinglin Yang, Qinqiang Long

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Abstract

The nuclear receptor peroxisome proliferator-activated receptor δ (PPARδ) can transcriptionally regulate target genes. PPARδ exerts essential regulatory functions in the heart, which requires constant energy supply. PPARδ plays a key role in energy metabolism, controlling not only fatty acid (FA) and glucose oxidation, but also redox homeostasis, mitochondrial biogenesis, inflammation, and cardiomyocyte proliferation. PPARδ signaling is impaired in the heart under various pathological conditions, such as pathological cardiac hypertrophy, myocardial ischemia/reperfusion, doxorubicin cardiotoxicity and diabetic cardiomyopathy. PPARδ deficiency in the heart leads to cardiac dysfunction, myocardial lipid accumulation, cardiac hypertrophy/remodeling and heart failure. This article provides an up-today overview of this research area and discusses the role of PPARδ in the heart in light of the complex mechanisms of its transcriptional regulation and its potential as a translatable therapeutic target for the treatment of cardiac disorders.

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PPARδ，心脏病的潜在治疗靶点。

核受体过氧化物酶体增殖激活受体δ（PPARδ）可以转录调节靶基因。PPARδ 在需要持续能量供应的心脏中发挥着重要的调节功能。PPARδ 在能量代谢中发挥关键作用，不仅控制脂肪酸（FA）和葡萄糖氧化，还控制氧化还原平衡、线粒体生物生成、炎症和心肌细胞增殖。在各种病理情况下，如病理性心肌肥厚、心肌缺血/再灌注、多柔比星心脏毒性和糖尿病心肌病等，心脏中的 PPARδ 信号都会受损。心脏中 PPARδ 的缺乏会导致心脏功能障碍、心肌脂质堆积、心脏肥大/重塑和心力衰竭。本文概述了这一研究领域的最新进展，并根据 PPARδ 转录调控的复杂机制及其作为治疗心脏疾病的可转化治疗靶点的潜力，讨论了 PPARδ 在心脏中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Receptor Research

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审稿时长

12 weeks