Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-03-21 eCollection Date: 2019-01-01 DOI:10.1155/2019/1096739

Adeseye Akinsete, Elizabeth Oyenusi, Babatunde Odugbemi, Tinuola Odugbemi, Edamisan Temiye

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引用次数: 2

Abstract

Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lagos, Nigeria. This was a cross-sectional study carried out at a teaching hospital with an antiretroviral therapy (ART) center. Serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) were analyzed in 83 children living with HIV on HAART and 51 controls. The prevalence of thyroid dysfunction and correlation of fT3, fT4, and TSH with duration on HAART, age, CD4 count, and nutritional status were assessed. Thyroid abnormalities were seen in 9.6% of the children living with HIV comprising subclinical hypothyroidism in 6%, euthyroid sick syndrome in 2.4%, and overt hypothyroidism in 1.2% as compared to 2% subclinical thyroid disease among the controls (p= 0.15). Hypothyroidism was correlated with CD4 count and viral load. None of the patients had clinical features of thyroid disease. Thyroid abnormalities were more prevalent among children living with HIV and yearly screening with follow-up is advocated.

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尼日利亚拉各斯感染艾滋病毒儿童甲状腺异常谱。

甲状腺疾病已在成人人群中被描述，但在儿童人群中被低估。本研究的目的是确定在尼日利亚拉各斯接受高效抗逆转录病毒治疗(HAART)的艾滋病毒感染儿童中甲状腺异常的患病率和谱。这是一项在具有抗逆转录病毒治疗(ART)中心的教学医院进行的横断面研究。分析了83例接受HAART治疗的HIV患儿血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(fT3)和游离甲状腺素(fT4)水平。评估甲状腺功能障碍的患病率以及fT3、fT4和TSH与HAART持续时间、年龄、CD4计数和营养状况的相关性。9.6%的艾滋病毒感染儿童出现甲状腺异常，包括6%的亚临床甲状腺功能减退，2.4%的甲状腺功能正常，1.2%的明显甲状腺功能减退，而对照组中有2%的亚临床甲状腺疾病(p= 0.15)。甲状腺功能减退与CD4计数和病毒载量相关。所有患者均无甲状腺疾病的临床特征。甲状腺异常在感染艾滋病毒的儿童中更为普遍，提倡每年进行筛查并随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.