The serum sclerostin level is positively associated with the aortic augmentation index in patients on peritoneal dialysis.

Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-04-01 DOI:10.4103/tcmj.tcmj_90_18

Lin Lin, Yu-Hsien Lai, Liang-Te Chiu, Jen-Pi Tsai, Chih-Hsien Wang, Bang-Gee Hsu

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Abstract

Objective: Sclerostin is a canonical Wingless (Wnt)/β-catenin signaling pathway inhibitor and had been associated with high arterial stiffness in patients with chronic kidney disease. The aortic augmentation index (AIx), a noninvasive method of assessing central hemodynamics/wave reflections, has been widely used as a clinical index of arterial stiffness. The aim of this study was to evaluate the relationship between fasting serum sclerostin levels and AIx values in peritoneal dialysis (PD) patients.

Materials and methods: Fasting blood samples were obtained from 75 PD patients. The aortic AIx value was measured using a validated tonometry system (SphygmoCor, AtCor Medical, Sydney, New South Wales, Australia). Serum sclerostin and dickkopf-1 (DKK1) levels were quantified using commercial enzyme-linked immunosorbent assay kits.

Results: Women PD patients had higher aortic AIx values than men (P = 0.039), while lower aortic AIx values were found in PD patients who used statins (P = 0.004). Univariate linear analysis of the aortic AIx values in PD patients showed that systolic blood pressure (P = 0.001), diastolic blood pressure (P = 0.018), and serum sclerostin levels (P = 0.001) were positively correlated, while height (P = 0.018), body weight (P = 0.001), body mass index (P = 0.043), and weekly total creatinine clearance (P = 0.015) were negatively correlated with aortic AIx values in PD patients. Multivariate linear regression analysis of the factors significantly associated with the aortic AIx values showed that serum sclerostin levels (adjusted R ² = 0.057, P = 0.011) and systolic blood pressure (adjusted R ² = 0.125, P = 0.004) were positively associated, while body weight (adjusted R ² = 0.113, P = 0.002) was inversely associated with aortic AIx values in PD patients.

Conclusion: In this study, the serum sclerostin level, but not DKK1, was positively associated with aortic AIx values in PD patients.

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腹膜透析患者的血清硬蛋白水平与主动脉增强指数呈正相关。

目的：硬蛋白是一种典型的无翼蛋白（Wnt）/β-catenin 信号通路抑制剂，与慢性肾病患者的高动脉僵化有关。主动脉增强指数（AIx）是一种评估中心血流动力学/波反射的无创方法，已被广泛用作动脉僵化的临床指标。本研究旨在评估腹膜透析（PD）患者空腹血清硬蛋白水平与 AIx 值之间的关系：从 75 名腹膜透析患者中采集空腹血样。材料和方法：从 75 名腹膜透析患者中采集空腹血样，使用经过验证的测压系统（SphygmoCor，AtCor Medical，澳大利亚新南威尔士州悉尼市）测量主动脉 AIx 值。使用商用酶联免疫吸附测定试剂盒对血清硬骨蛋白和dickkopf-1（DKK1）水平进行量化：女性帕金森病患者的主动脉AIx值高于男性（P = 0.039），而使用他汀类药物的帕金森病患者的主动脉AIx值低于男性（P = 0.004）。对 PD 患者主动脉 AIx 值的单变量线性分析表明，收缩压（P = 0.001）、舒张压（P = 0.018）和血清硬蛋白水平（P = 0.001）呈正相关，而身高（P = 0.018）、体重（P = 0.001）、体质指数（P = 0.043）和每周总肌酐清除率（P = 0.015）与 PD 患者的主动脉 AIx 值呈负相关。对与主动脉AIx值明显相关的因素进行的多变量线性回归分析表明，血清硬化剂水平（调整后R 2 = 0.057，P = 0.011）和收缩压（调整后R 2 = 0.125，P = 0.004）与主动脉AIx值呈正相关，而体重（调整后R 2 = 0.113，P = 0.002）与PD患者的主动脉AIx值呈反相关：结论：在本研究中，血清硬骨生成素水平（而非 DKK1）与帕金森病患者的主动脉 AIx 值呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ci ji yi xue za zhi = Tzu-chi medical journal

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