Anti-inflammatory Effect of Woodfordia fructicosa Leaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats.

Q2 Medicine

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2020-01-01 DOI:10.2174/1871523018666190222120127

Hem Raj, Avneet Gupta, Neeraj Upmanyu

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Abstract

Background: Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis.

Methods: In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund's adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni's test was used for statistical analysis.

Results: WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF- α was observed.

Conclusion: These results showed that the WFEexerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by preventing the inflammation in different animal models.

Abstract Image

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木福特叶乙醇提取物对佐剂和卡拉胶治疗大鼠的抗炎作用。

背景:枸杞子传统上用于治疗关节炎相关炎症。方法:采用200 mg/kg剂量口服枸杞子叶乙醇提取物对大鼠的抗炎作用进行研究。以卡拉胶致足跖水肿、弗氏佐剂(FA)和醋酸碘钠(MIA)致关节炎为动物模型，研究炎症反应。测定FA处理动物血液样本中血清肿瘤坏死因子-α (TNF-α)的含量。采用Bonferroni检验后的单因素方差分析进行统计分析。结果:WFE显著降低(p)。结论:WFE对TNF-α和卡拉胶足跖水肿具有抑制作用，证明了其在炎症条件下的传统应用是合理的。因此，本研究表明，在不同的动物模型中，水仙花叶具有抗炎作用。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.