Double Poisson-Tweedie Regression Models.

IF 1.2 4区 数学 Q4 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Ricardo R Petterle, Wagner H Bonat, Célestin C Kokonendji, Juliane C Seganfredo, Atamai Moraes, Monica G da Silva
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引用次数: 13

Abstract

In this paper, we further extend the recently proposed Poisson-Tweedie regression models to include a linear predictor for the dispersion as well as for the expectation of the count response variable. The family of the considered models is specified using only second-moments assumptions, where the variance of the count response has the form μ+ϕμp $\mu + \phi \mu^p$, where µ is the expectation, ϕ and p are the dispersion and power parameters, respectively. Parameter estimations are carried out using an estimating function approach obtained by combining the quasi-score and Pearson estimating functions. The performance of the fitting algorithm is investigated through simulation studies. The results showed that our estimating function approach provides consistent estimators for both mean and dispersion parameters. The class of models is motivated by a data set concerning CD4 counting in HIV-positive pregnant women assisted in a public hospital in Curitiba, Paraná, Brazil. Specifically, we investigate the effects of a set of covariates in both expectation and dispersion structures. Our results showed that women living out of the capital Curitiba, with viral load equal or larger than 1000 copies and with previous diagnostic of HIV infection, present lower levels of CD4 cell count. Furthermore, we detected that the time to initiate the antiretroviral therapy decreases the data dispersion. The data set and R code are available as supplementary materials.

双泊松- tweedie回归模型。
在本文中,我们进一步扩展了最近提出的Poisson-Tweedie回归模型,以包括色散的线性预测器以及计数响应变量的期望。所考虑的模型族仅使用秒矩假设来指定,其中计数响应的方差具有μ+ϕμp $\mu + \phi \mu^p$的形式,其中µ是期望,ϕ和p分别是色散和功率参数。参数估计采用拟分数和Pearson估计函数相结合的估计函数方法进行。通过仿真研究对拟合算法的性能进行了研究。结果表明,我们的估计函数方法对平均参数和离散参数都提供了一致的估计。这类模型的灵感来自于巴西帕拉纳岛库里蒂巴一家公立医院协助的艾滋病毒阳性孕妇的CD4计数数据集。具体来说,我们研究了一组协变量在期望和分散结构中的影响。我们的研究结果表明,居住在首都库里提巴以外的妇女,病毒载量等于或大于1000拷贝,并且以前被诊断为HIV感染,CD4细胞计数水平较低。此外,我们发现开始抗逆转录病毒治疗的时间减少了数据的离散性。数据集和R代码作为补充资料。
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来源期刊
International Journal of Biostatistics
International Journal of Biostatistics MATHEMATICAL & COMPUTATIONAL BIOLOGY-STATISTICS & PROBABILITY
CiteScore
2.10
自引率
8.30%
发文量
28
审稿时长
>12 weeks
期刊介绍: The International Journal of Biostatistics (IJB) seeks to publish new biostatistical models and methods, new statistical theory, as well as original applications of statistical methods, for important practical problems arising from the biological, medical, public health, and agricultural sciences with an emphasis on semiparametric methods. Given many alternatives to publish exist within biostatistics, IJB offers a place to publish for research in biostatistics focusing on modern methods, often based on machine-learning and other data-adaptive methodologies, as well as providing a unique reading experience that compels the author to be explicit about the statistical inference problem addressed by the paper. IJB is intended that the journal cover the entire range of biostatistics, from theoretical advances to relevant and sensible translations of a practical problem into a statistical framework. Electronic publication also allows for data and software code to be appended, and opens the door for reproducible research allowing readers to easily replicate analyses described in a paper. Both original research and review articles will be warmly received, as will articles applying sound statistical methods to practical problems.
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