Expression and clinical significance of serum NT5E protein in patients with colorectal cancer.

IF 1.9
Gang Wang, Shan Fu, Dechuan Li, Yinbo Chen
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引用次数: 5

Abstract

Objective: This study aimed to investigate the expression level and clinical significance of serum NT5E protein (ecto-5'-nucleotidase) in patients with colorectal cancer.

Methods: The expression level of serum NT5E protein in 232 patients with colorectal cancer and 158 normal controls was detected using enzyme-linked immunosorbent assay. Moreover, the relationship between the expression level of serum NT5E and the clinicopathological features of colorectal cancer was analyzed.

Results: The expression level of serum NT5E in patients with colorectal cancer was significantly higher compared with that in normal controls (P< 0.05). The expression level of serum NT5E in patients with colorectal cancer closely correlated with the family history of tumors (P= 0.001), expression level of CA19-9 (P= 0.031), lymph node metastasis (P= 0.001), distant metastasis (P= 0.010), nerve invasion (P= 0.049), degree of differentiation (P= 0.013), and TNM staging (P= 0.001), but not with gender, age, smoking and drinking histories, expression level of carcinoembryonic antigen (CEA), tumor locations, vascular tumor thrombus, cancer nodules, and pathological type (P> 0.05). Moreover, the overall survival rate of patients with colorectal cancer was significantly lower in the NT5E high-expression group, with statistical significance (χ2= 11.184, P= 0.001).

Conclusions: The expression level of serum NT5E increased in patients with colorectal cancer, and closely correlated with the malignant evolution and clinical prognosis of colorectal cancer. NT5E might serve as a serological indicator for molecular diagnosis and prognosis of colorectal cancer clinically.

结直肠癌患者血清NT5E蛋白表达及临床意义
目的:探讨结直肠癌患者血清NT5E蛋白(ecto-5′-核苷酸酶)的表达水平及临床意义。方法:采用酶联免疫吸附法检测232例结直肠癌患者和158例正常人血清NT5E蛋白的表达水平。分析血清NT5E表达水平与结直肠癌临床病理特征的关系。结果:结直肠癌患者血清NT5E表达水平明显高于正常对照组(P< 0.05)。结直肠癌患者血清NT5E表达水平与肿瘤家族史(P= 0.001)、CA19-9表达水平(P= 0.031)、淋巴结转移(P= 0.001)、远处转移(P= 0.010)、神经侵犯(P= 0.049)、分化程度(P= 0.013)、TNM分期(P= 0.001)密切相关,而与性别、年龄、吸烟、饮酒史、癌胚抗原(CEA)表达水平、肿瘤部位、血管肿瘤血栓、癌结节、病理分型(P> 0.05)。NT5E高表达组结直肠癌患者总生存率显著降低,差异有统计学意义(χ2= 11.184, P= 0.001)。结论:血清NT5E在结直肠癌患者中表达水平升高,且与结直肠癌的恶性演变及临床预后密切相关。NT5E可作为临床大肠癌分子诊断及预后的血清学指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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