Oral Hairy Leukoplakia in Patients With No Evidence of Immunosuppression: A Case Series and Review of the Literature.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2018-05-01

Mark Roger Darling, Morad Alkhasawneh, Wendall Mascarenhas, Alexandra Chirila, Maria Copete

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引用次数: 0

Abstract

Objectives: Oral hairy leukoplakia (OHL) is caused by Epstein-Barr virus (EBV) and is often associated with HIV and other immunosuppressive conditions. It is rare in HIV-negative patients, but has been reported in patients who use immune-modulating medications (e.g., cyclosporine). The objectives of this study were to determine the occurrence of OHL in HIV-negative patients and report Langerhans cell counts in these lesions.

Study design: A series of 7 new cases of OHL among HIV-negative patients is described. Langerhans cells were counted using an immunoperoxidase stain for CD1a and light microscopy.

Results: The 7 patients were male, ranging in age from 26 to 69 years. Clinically, all lesions were diagnosed as leukoplakia on the lateral border of the tongue. Microscopic examination revealed hyperparakeratosis and candidiasis in some cases, acanthosis and a band-like zone with clearing of cells in the upper spinous layer, which were EBV-positive by in-situ hybridization. There was a significant decrease in Langerhans cell counts in OHL patients.

Conclusion: OHL can occur in HIV-negative patients.

本刊更多论文

无免疫抑制证据的口腔毛状白斑:一个病例系列和文献综述。

目的:口腔毛状白斑(OHL)是由eb病毒(EBV)引起的，通常与HIV和其他免疫抑制疾病有关。它在hiv阴性患者中很少见，但在使用免疫调节药物(如环孢素)的患者中有报道。本研究的目的是确定艾滋病毒阴性患者中OHL的发生率，并报告这些病变中的朗格汉斯细胞计数。研究设计:描述了一系列hiv阴性患者中7例新的OHL病例。使用CD1a免疫过氧化物酶染色和光镜对朗格汉斯细胞进行计数。结果:7例患者为男性，年龄26 ~ 69岁。临床均诊断为舌侧缘白斑。镜检显示部分病例角化过度，念珠菌感染，棘层增生，棘层上部细胞清除带状带，原位杂交显示ebv阳性。OHL患者朗格汉斯细胞计数明显下降。结论:OHL可发生于hiv阴性患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.