Genome Sequencing and Annotation of Bacillus subtilis UBBS-14 to Ensure Probiotic Safety.

Journal of Genomics Pub Date : 2019-01-29 eCollection Date: 2019-01-01 DOI:10.7150/jgen.31170
Ayesha Sulthana, Suvarna G Lakshmi, Ratna Sudha Madempudi
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引用次数: 4

Abstract

Bacillus subtilis is a rod shaped, gram positive, spore producing bacterium. They are the normal flora of gastrointestinal tract of humans and it is the best characterized model organism for endospore formation. It has the ability to withstand environmental stress, and synthesize beneficial compounds, therefore, it is recognized as a high-quality probiotic supplement. To ensure the probiotic safety and the efficiency, we report the whole genome sequence (WGS) of Bacillus subtilis UBBS-14 strain. The draft genome sequence of Bacillus subtilis UBBS-14 consists of 4,048,984 bp and 4,017 genes, respectively. Bacillus subtilis UBBS-14 does not carry any antibiotic resistant genes containing plasmid, nor it contains any harmful putative virulence factors coding genes, therefore, it confirms the probiotic safety of the respective strain at genome level.

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枯草芽孢杆菌UBBS-14的基因组测序和注释确保益生菌的安全性。
枯草芽孢杆菌是一种杆状、革兰氏阳性、产孢子的细菌。它们是人类胃肠道的正常菌群,是孢子内形成的最具特征的模式生物。它具有承受环境压力的能力,并能合成有益的化合物,因此,它是公认的优质益生菌补充剂。为了保证益生菌的安全性和有效性,我们报道了枯草芽孢杆菌UBBS-14菌株的全基因组序列(WGS)。枯草芽孢杆菌UBBS-14的基因组草图序列分别包含4048,984 bp和4017个基因。枯草芽孢杆菌UBBS-14不携带任何含质粒的抗生素耐药基因,也不含有任何有害的推定毒力因子编码基因,因此在基因组水平上证实了相应菌株的益生菌安全性。
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来源期刊
自引率
0.00%
发文量
11
审稿时长
12 weeks
期刊介绍: Journal of Genomics publishes papers of high quality in all areas of gene, genetics, genomics, proteomics, metabolomics, DNA/RNA, computational biology, bioinformatics, and other relevant areas of research and application. Articles published by the journal are rigorously peer-reviewed. Types of articles include: Research paper, Short research communication, Review or mini-reviews, Commentary, Database, Software.
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