Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population.

Q2 Biochemistry, Genetics and Molecular Biology

BMC Biochemistry Pub Date : 2019-02-06 DOI:10.1186/s12858-019-0106-3

Yuan Li, Shousheng Liu, Yuqiang Gao, Huan Ma, Shuhui Zhan, Yan Yang, Yongning Xin, Shiying Xuan

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引用次数: 14

Abstract

Background: Genetic factors affect the risk of non-alcoholic fatty liver disease (NAFLD) and colorectal adenoma (CRA) importantly. Transmembrane protein 6 superfamily member 2 (TM6SF2) rs58542926 is a significant genetic susceptibility site for NAFLD. The relationships of TM6SF2 rs58542926 with the risk of NAFLD and CRA in Chinese Han population were unclear. The aim of this study was to investigate the association of TM6SF2 rs58542926 with the risk of NAFLD and CRA, and the effect of CRA on TM6SF2 rs58542926 carried NAFLD patients.

Results: A total of 839 Chinese Han population were included in this retrospective study. TM6SF2 rs58542926 polymorphism was genotyped in B-type ultrasonography proven NAFLD patients with or without CRA, CRA patients and healthy controls, using polymerase chain reaction. Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS statistical software, version 16.0 for mac. There was a significant difference in the distribution of genotype and allele of TM6SF2 rs58542926 in NAFLD and NAFLD&CRA patients compared to controls. The CT + TT genotypes were tightly associated with the risk of NAFLD and NAFLD&CRA. TM6SF2 rs58542926 T allele promotes the abnormal regulation of lipids metabolism and liver injury in NAFLD patients and NAFLD&CRA patients. CRA aggravates the clinical performance of NAFLD in T allele carriers.

Conclusions: We demonstrated the significant association between TM6SF2 rs58542926 polymorphism and the risk of NAFLD and NAFLD&CRA in a Chinese Han population. The TM6SF2 rs58542926 T allele promotes the abnormal regulation of lipid profiles and liver injury in NAFLD patients, NAFLD&CRA patients, and overall subjects.

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中国汉族人群TM6SF2 rs58542926基因多态性与非酒精性脂肪肝和结直肠腺瘤风险的关系

背景:遗传因素对非酒精性脂肪性肝病(NAFLD)和结直肠腺瘤(CRA)的发病风险有重要影响。跨膜蛋白6超家族成员2 (TM6SF2) rs58542926是NAFLD的重要遗传易感位点。TM6SF2 rs58542926与中国汉族人群NAFLD和CRA风险的关系尚不清楚。本研究旨在探讨TM6SF2 rs58542926与NAFLD和CRA风险的相关性，以及CRA对携带TM6SF2 rs58542926的NAFLD患者的影响。结果:本回顾性研究共纳入839名汉族人群。采用聚合酶链反应对b型超声证实合并或不合并CRA的NAFLD患者、CRA患者和健康对照组的TM6SF2 rs58542926多态性进行基因分型。采用生化法测定血脂。采用SPSS统计软件(mac版16.0)进行统计学分析。TM6SF2 rs58542926基因型和等位基因在NAFLD和NAFLD& cra患者中的分布与对照组比较差异有统计学意义。CT + TT基因型与NAFLD及NAFLD& cra风险密切相关。TM6SF2 rs58542926 T等位基因促进NAFLD患者及NAFLD& cra患者脂质代谢和肝损伤的异常调节。CRA加重T等位基因携带者NAFLD的临床表现。结论:我们证明了TM6SF2 rs58542926多态性与中国汉族人群NAFLD和NAFLD& cra风险之间的显著相关性。TM6SF2 rs58542926 T等位基因可促进NAFLD患者、NAFLD& cra患者以及整体受试者的脂质谱异常调节和肝损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： BMC Biochemistry is an open access journal publishing original peer-reviewed research articles in all aspects of biochemical processes, including the structure, function and dynamics of metabolic pathways, supramolecular complexes, enzymes, proteins, nucleic acids and small molecular components of organelles, cells and tissues. BMC Biochemistry (ISSN 1471-2091) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, Zoological Record, Thomson Reuters (ISI) and Google Scholar.