Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non-surgical periodontal treatment in chronic periodontitis

Q1 Medicine

Journal of Investigative and Clinical Dentistry Pub Date : 2019-01-20 DOI:10.1111/jicd.12393

Sana Ikram, Nuzhat Hassan, Saeeda Baig, Kevin Joseph Jerome Borges, Muhammad Arsalan Raffat, Zohaib Akram

{"title":"Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non-surgical periodontal treatment in chronic periodontitis","authors":"Sana Ikram, Nuzhat Hassan, Saeeda Baig, Kevin Joseph Jerome Borges, Muhammad Arsalan Raffat, Zohaib Akram","doi":"10.1111/jicd.12393","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>The aim of the present study was to assess and compare the clinical efficacy of local probiotic <i>Lactobacillus reuteri</i> (<i>L. reuteri</i>) and systemic antibiotics as adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Thirty systemically-healthy participants (15 probiotic and 15 antibiotic), clinically diagnosed with CP, were enrolled. All patients underwent SRP. Adjunctive probiotics were administered twice daily for 3 months, whereas a combination of amoxicillin and metronidazole were given three times daily for 7 days.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Intragroup analysis showed statistically-significant improvement in all clinical parameters: plaque index, bleeding on probing, periodontal pocket depth, and clinical attachment level gain at each follow-up visit. However, intergroup comparison of clinical periodontal parameters did not show statistical significance.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The adjunctive use of <i>L. reuteri</i> and systemic antibiotics along with SRP showed similar improvement in all clinical periodontal parameters. This indicates that both adjunctive therapeutic agents showed similar efficacy in resolving inflammation and improving periodontal outcomes.</p>\n </section>\n </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12393","citationCount":"33","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative and Clinical Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jicd.12393","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 33

Abstract

Aim

The aim of the present study was to assess and compare the clinical efficacy of local probiotic Lactobacillus reuteri (L. reuteri) and systemic antibiotics as adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP).

Methods

Thirty systemically-healthy participants (15 probiotic and 15 antibiotic), clinically diagnosed with CP, were enrolled. All patients underwent SRP. Adjunctive probiotics were administered twice daily for 3 months, whereas a combination of amoxicillin and metronidazole were given three times daily for 7 days.

Results

Intragroup analysis showed statistically-significant improvement in all clinical parameters: plaque index, bleeding on probing, periodontal pocket depth, and clinical attachment level gain at each follow-up visit. However, intergroup comparison of clinical periodontal parameters did not show statistical significance.

Conclusion

The adjunctive use of L. reuteri and systemic antibiotics along with SRP showed similar improvement in all clinical periodontal parameters. This indicates that both adjunctive therapeutic agents showed similar efficacy in resolving inflammation and improving periodontal outcomes.

查看原文本刊更多论文

局部益生菌(罗伊氏乳杆菌)与全身抗生素治疗作为非手术牙周治疗辅助治疗慢性牙周炎的效果

目的评价和比较局部益生菌罗伊氏乳杆菌(L. reuteri)与全身抗生素联合刮治和根治(SRP)治疗慢性牙周炎(CP)的临床疗效。方法30例临床诊断为CP的全身健康受试者(益生菌组15例，抗生素组15例)。所有患者均行SRP。辅助益生菌每天两次，持续3个月，而阿莫西林和甲硝唑的组合每天三次，持续7天。结果组内分析显示，所有临床参数均有统计学意义上的改善:斑块指数、探诊出血、牙周袋深度和每次随访时的临床依恋水平增加。两组间临床牙周参数比较无统计学意义。结论辅助使用罗伊氏乳杆菌和全身抗生素与SRP对临床牙周指标的改善效果相似。这表明两种辅助治疗药物在解决炎症和改善牙周预后方面表现出相似的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.