Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health.

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2018-02-01 Epub Date: 2018-11-13 DOI:10.1515/pteridines-2018-0013

Hina Makkar, Mark A Reynolds, Abhishek Wadhawan, Aline Dagdag, Anwar T Merchant, Teodor T Postolache

引用次数: 0

Abstract

Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.

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牙周病、新陈代谢和心血管疾病：探索炎症和心理健康的作用。

牙周病是影响大多数美国人的一种可改变的疾病，以往的证据表明，牙周病与代谢和心血管疾病的发病率和死亡率有关。这篇综述的重点是免疫激活对这些关联的可能调解作用及其与精神疾病的潜在相互作用。未来的纵向研究，最好是干预性研究，应重点关注相互影响和连带效应，以及跨诊断领域的有效预防和治疗干预措施，以降低发病率和死亡率，提高生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.