{"title":"Survivin and insulin-like growth factor-I: potential role in the pathogenesis of acne and post-acne scar.","authors":"Samar El-Tahlawi, Noha Ezzat Mohammad, Azza Mohamed El-Amir, Heba Sayed Mohamed","doi":"10.1177/2059513118818031","DOIUrl":null,"url":null,"abstract":"<p><strong>Backgrounds/objectives: </strong>Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their potential role in pathogenesis in acne and post-acne scar.</p><p><strong>Methods: </strong>Serum survivin and IGF-I levels were estimated in 30 patients with acne and post-acne scar compared to 30 controls.</p><p><strong>Results: </strong>There was a statistically significant difference in survivin and IGF-I levels between controls and patients (<i>P</i> < 0.05). However, there was no linear correlation between survivin and IGF-I.</p><p><strong>Conclusions: </strong>Survivin and IGF-I could have a possible role in the pathogenesis of active acne and in post-inflammatory acne scar.</p>","PeriodicalId":21495,"journal":{"name":"Scars, burns & healing","volume":"5 ","pages":"2059513118818031"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2059513118818031","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scars, burns & healing","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2059513118818031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
Backgrounds/objectives: Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their potential role in pathogenesis in acne and post-acne scar.
Methods: Serum survivin and IGF-I levels were estimated in 30 patients with acne and post-acne scar compared to 30 controls.
Results: There was a statistically significant difference in survivin and IGF-I levels between controls and patients (P < 0.05). However, there was no linear correlation between survivin and IGF-I.
Conclusions: Survivin and IGF-I could have a possible role in the pathogenesis of active acne and in post-inflammatory acne scar.
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