Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2019-01-01 DOI:10.2174/1871525717666190121143934

Mohammed Ajebli, Mohamed Eddouks

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Abstract

Background and objective: Warionia saharae Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from Warionia saharae (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats.

Methods: Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of FEE were carried out in this study.

Results: Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.

Conclusion: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.

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沙漠植物 Warionia saharae 的黄酮类富集提取物能改善糖尿病大鼠的血糖和胆固醇水平

背景和目的：Warionia saharae Benth and Coss 是摩洛哥的一种药用植物，具有抗糖尿病的功效。本研究旨在探讨从 Warionia saharae（W. saharae）中提取的黄酮类富集提取物（FEE）对正常大鼠和链脲佐菌素（STZ）诱导的糖尿病大鼠葡萄糖和脂质代谢的影响：方法：采用急性（6 小时）和亚慢性（15 天）口服 FEE（10 毫克/千克）来评估正常大鼠和糖尿病大鼠的降糖和降脂活性。此外，本研究还对 FEE 的葡萄糖耐受试验、肝脏组织病理学检查和体外抗氧化活性进行了评估：结果表明，FEE 具有降血糖活性。此外，FEE 还能改善糖尿病大鼠肝脏和胰腺的组织病理学状况，并具有抗氧化活性：总之，本研究揭示了 FEE 对糖尿病大鼠具有有效的抗糖尿病作用。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.