The Incidental Use of High-Dose Vitamin D3 in Pancreatic Cancer.

Case reports in pancreatic cancer Pub Date : 2016-05-01 eCollection Date: 2016-01-01 DOI:10.1089/crpc.2016.0003
Timothy L Cannon, Joel Ford, Danubia Hester, Donald L Trump
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引用次数: 3

Abstract

Background: Pancreatic adenocarcinoma is associated with a very poor prognosis, with a 5 year survival of ∼7.2%. Vitamin D has long been evaluated for benefit as a protective agent and treatment for malignancies. Although cancer incidence and outcomes have been tied to vitamin D levels, there is no clear evidence that supplementation of vitamin D improves outcome in pancreatic cancer to date. Case Presentation: We present a patient who errantly took supratherapeutic doses of vitamin D 50,000 U daily, achieving a serum 25(OH)D level of more than 150 mg/mL, with no appreciable side effects. Conclusion: Her disease was stable for 8 months off of conventional treatment, although it is unclear whether this was related to vitamin D supplementation.

Abstract Image

高剂量维生素D3在胰腺癌中的偶然使用。
背景:胰腺腺癌的预后非常差,5年生存率约为7.2%。维生素D作为一种保护剂和治疗恶性肿瘤的益处早已被评估。虽然癌症的发病率和预后与维生素D水平有关,但迄今为止没有明确的证据表明补充维生素D可以改善胰腺癌的预后。病例介绍:我们报告了一名患者,他每天服用超治疗剂量的维生素D 50,000 U,达到血清25(OH)D水平超过150 mg/mL,没有明显的副作用。结论:在常规治疗结束后的8个月,患者病情稳定,但尚不清楚这是否与补充维生素D有关。
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