Preoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Not Clinically Useful in Predicting Prognosis in Early Stage Cervical Cancer.

Surgery Research and Practice Pub Date : 2018-12-02 eCollection Date: 2018-01-01 DOI:10.1155/2018/9162921

Prachratana Nuchpramool, Jitti Hanprasertpong

{"title":"Preoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Not Clinically Useful in Predicting Prognosis in Early Stage Cervical Cancer.","authors":"Prachratana Nuchpramool, Jitti Hanprasertpong","doi":"10.1155/2018/9162921","DOIUrl":null,"url":null,"abstract":"Background: An objective of this study was to determine the prognostic role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (CC) stages IA2-IB1.Methods: The study included 484 patients who underwent radical hysterectomy with pelvic node dissection. The associations of preoperative NLR and PLR with clinicopathologic characteristics and oncological outcomes were analyzed. The cut-off values of NLR (=1.8) and PLR (=119) were set as medians.Results: The clinicopathologic analysis showed that NLR was associated with age (p=0.010), tumor size (p=0.045), and adjuvant treatment (p=0.005), and PLR was associated with only adjuvant treatment (p=0.033). DFS and OS were not significantly different between patients with high and low NLR (p=0.670 and p=0.934) or high and low PLR (p=0.780 and p=0.306). The independent prognostic factors associated with OS were lymph node status and anemia, and with DFS were histology, deep stromal invasion, and lymph node status.Conclusions: NLR and PLR have no use as prognostic biomarker for DFS and OS in early-stage CC. However, NLR and PLR might be of use in determining the risk for adjuvant treatment.","PeriodicalId":30584,"journal":{"name":"Surgery Research and Practice","volume":"2018 ","pages":"9162921"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/9162921","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgery Research and Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2018/9162921","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 15

Abstract

Background: An objective of this study was to determine the prognostic role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (CC) stages IA2-IB1.

Methods: The study included 484 patients who underwent radical hysterectomy with pelvic node dissection. The associations of preoperative NLR and PLR with clinicopathologic characteristics and oncological outcomes were analyzed. The cut-off values of NLR (=1.8) and PLR (=119) were set as medians.

Results: The clinicopathologic analysis showed that NLR was associated with age (p=0.010), tumor size (p=0.045), and adjuvant treatment (p=0.005), and PLR was associated with only adjuvant treatment (p=0.033). DFS and OS were not significantly different between patients with high and low NLR (p=0.670 and p=0.934) or high and low PLR (p=0.780 and p=0.306). The independent prognostic factors associated with OS were lymph node status and anemia, and with DFS were histology, deep stromal invasion, and lymph node status.

Conclusions: NLR and PLR have no use as prognostic biomarker for DFS and OS in early-stage CC. However, NLR and PLR might be of use in determining the risk for adjuvant treatment.

Abstract Image

查看原文本刊更多论文

术前中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值对早期宫颈癌的预后无临床意义。

背景:本研究的目的是确定中性粒细胞-淋巴细胞比率(NLR)和血小板-淋巴细胞比率(PLR)在宫颈癌(CC) IA2-IB1期患者中的预后作用。方法:本研究纳入484例行根治性子宫切除术合并盆腔淋巴结清扫术的患者。分析术前NLR和PLR与临床病理特征和肿瘤预后的关系。NLR(=1.8)和PLR(=119)的临界值设为中位数。结果:临床病理分析显示NLR与年龄(p=0.010)、肿瘤大小(p=0.045)、辅助治疗(p=0.005)相关，PLR仅与辅助治疗相关(p=0.033)。高、低NLR组(p=0.670和p=0.934)、高、低PLR组(p=0.780和p=0.306)患者的DFS和OS差异无统计学意义。与OS相关的独立预后因素是淋巴结状态和贫血，与DFS相关的是组织学、深部基质浸润和淋巴结状态。结论:NLR和PLR不能作为早期CC患者DFS和OS的预后生物标志物，但NLR和PLR可能用于确定辅助治疗的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Surgery Research and Practice

自引率

0.00%

发文量

期刊介绍： Surgery Research and Practice is a peer-reviewed, Open Access journal that provides a forum for surgeons and the surgical research community. The journal publishes original research articles, review articles, and clinical studies focusing on clinical and laboratory research relevant to surgical practice and teaching, with an emphasis on findings directly affecting surgical management.