Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, and Carbohydrate Antigen 72-4 in Gastric Cancer: Is the Old Band Still Playing?

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY
Gastrointestinal Tumors Pub Date : 2018-09-01 Epub Date: 2018-04-24 DOI:10.1159/000488240
Andrey Iskrenov Kotzev, Peter Vassilev Draganov
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引用次数: 28

Abstract

Background: Gastric cancer (GC) is characterized by aggressive behavior and a high mortality rate. The diagnosis of GC is challenging because the GC is often diagnosed in an advanced stage. The use of tumor markers is a putative way to improve the detection and treatment in patients with GC.

Summary: In this article, we review the significance of serum carbohydrate antigen (CA) 19-9, carcinoembryonic antigen (CEA), and CA 72-4 in GC. The results from different studies regarding the diagnostic and prognostic role of CA 19-9, CEA, and CA 72-4 in GC are encouraging, but inadequate sensitivity and specificity obstruct their use as standardized and unconditionally reliable markers in GC. New prospective clinical trials are mandatory for clarifying their value in GC.

Key message: CA 19-9, CEA, and CA 72-4 should not be used for screening and early diagnosis in GC, whereas they are beneficial in the detection of late GC. CA 19-9, CEA, and CA 72-4 could be used as prognostic and monitoring tools in GC, and their combined measurement in shorter periods of time is the best method to increase sensitivity and specificity.

Practical implications: Serum CA 19-9, CEA, and CA 72-4 are useful diagnostic and prognostic tumor markers in GC.

碳水化合物抗原19-9、癌胚抗原和碳水化合物抗原72-4在胃癌中的作用:老乐队还在演奏吗?
背景:胃癌具有侵袭性行为和高死亡率的特点。胃癌的诊断具有挑战性,因为胃癌通常在晚期诊断。肿瘤标志物的使用被认为是提高胃癌患者的检测和治疗的一种方法。摘要:本文综述了血清碳水化合物抗原(CA) 19-9、癌胚抗原(CEA)和CA 72-4在胃癌中的意义。关于CA 19-9、CEA和CA 72-4在胃癌中的诊断和预后作用的不同研究结果令人鼓舞,但灵敏度和特异性不足阻碍了它们作为胃癌标准化和无条件可靠的标志物的使用。新的前瞻性临床试验必须明确其在GC中的价值。关键信息:CA 19-9、CEA和CA 72-4不应用于胃癌的筛查和早期诊断,而它们对晚期胃癌的检测是有益的。CA 19-9、CEA和CA 72-4可作为GC的预后和监测工具,在较短时间内联合检测是提高敏感性和特异性的最佳方法。实际意义:血清ca19 -9、CEA和ca72 -4是胃癌有用的诊断和预后肿瘤标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gastrointestinal Tumors
Gastrointestinal Tumors GASTROENTEROLOGY & HEPATOLOGY-
自引率
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发文量
5
审稿时长
17 weeks
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