Fabiola Marín-Aguilar, Jesús Ruiz-Cabello, Mario D Cordero
{"title":"Aging and the Inflammasomes.","authors":"Fabiola Marín-Aguilar, Jesús Ruiz-Cabello, Mario D Cordero","doi":"10.1007/978-3-319-89390-7_13","DOIUrl":null,"url":null,"abstract":"<p><p>The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis. It is broadly considered that chronic inflammation may be a common link in age-related diseases, aging being the greatest risk factor for the development of chronic diseases. In this sense, we discuss the role of inflammasomes in non-infectious inflammation and their interest in aging and age-related diseases.</p>","PeriodicalId":36906,"journal":{"name":"Experientia supplementum (2012)","volume":"108 ","pages":"303-320"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-319-89390-7_13","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experientia supplementum (2012)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-319-89390-7_13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 11
Abstract
The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory cytokines, Il1b and IL18, and a particular inflammatory type of cell death termed pyroptosis. It is broadly considered that chronic inflammation may be a common link in age-related diseases, aging being the greatest risk factor for the development of chronic diseases. In this sense, we discuss the role of inflammasomes in non-infectious inflammation and their interest in aging and age-related diseases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
