MBL2 rs7095891 G > A polymorphism was associated with an increased risk of tuberculosis in the Chinese Uygur population.

Abstract

Introduction: Tuberculosis (TB) is a foremost infectious disease in most parts of the world. Globally, tuberculosis is the second-leading cause of infectious diseases. This has become a significant world-wide social and public health issue, and one of the major diseases in China. In addition to environmental risk factors, genetic factors may play an important role in the development of tuberculosis.

Methods: We conducted a case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): MBL2 rs1800450 C > T, MBL2 rs7095891 G > A and MBL2 rs7096206 C > G, and their influences on the development of tuberculosis. A total of 231 tuberculosis cases and 240 controls were included in this study. Genotypes were determined using a custom-designed 48-Plex SNPscanTM kit.

Results: The MBL2 rs7095891 G > A polymorphism was associated with an increased risk of TB. However, there were no significant links with the other two SNPs. In any subgroup, there was no relvant risk of TB associated with MBL2 rs7095891 G > A polymorphism.

Conclusion: These findings suggest that functional polymorphism MBL2 rs7095891 G > A may be positively correlated with susceptibility to tuberculosis. These findings may be somewhat limited by sample size. A further study with more focus on different regions, ethnic groups and larger sample sizes is therefore suggested.