Association Between STAT4 rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.

Pub Date : 2018-10-24 eCollection Date: 2018-01-01 DOI:10.2174/1874312901812010172

Iman Tarakji, Wafa Habbal, Fawza Monem

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引用次数: 7

Abstract

Background: STAT4 rs7574865 polymorphism has been evidently associated with susceptibility to Rheumatoid Arthritis (RA) in European and Eastern Asian populations, whereas studies in other countries reported otherwise.

Objective: We investigated the distribution of STAT4 rs7574865 polymorphism in a group of Syrian RA patients.

Methods: Eighty-one RA patients and forty healthy controls were enrolled and STAT4 rs7574865 was genotyped by direct sequencing. RA patients were stratified according to Anti-Citrullinated Protein Antibodies (ACPA) status for analysis.

Results: Minor T allele frequencies were 30.4%, 16.7%, and 23.8% in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively. No significant differences in STAT4 rs7574865 allele/genotype frequencies were found between ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls (P>0.05).

Conclusion: STAT4 rs7574865 TT genotype showed a potential impact on ACPA positivity in Syrian RA patients. However, STAT4 rs7574865 effect on RA onset and severity is minor compared to other genetic factors such as HLA-DRB1 shared epitope alleles.

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STAT4 rs7574865多态性与类风湿关节炎的关系:尚未解决的争论

背景:STAT4 rs7574865多态性在欧洲和东亚人群中与类风湿关节炎(RA)易感性明显相关，而其他国家的研究报告则相反。目的:研究STAT4 rs7574865多态性在叙利亚RA患者中的分布。方法:选取81例RA患者和40例健康对照者，采用直接测序法对STAT4 rs7574865进行基因分型。根据抗瓜氨酸蛋白抗体(Anti-Citrullinated Protein Antibodies, ACPA)水平对RA患者进行分层分析。结果:次要T等位基因频率在acpa阳性RA患者、acpa阴性RA患者和健康对照中分别为30.4%、16.7%和23.8%。STAT4 rs7574865等位基因/基因型频率在acpa阳性RA患者、acpa阴性RA患者和健康对照组之间无显著差异(P>0.05)。结论:STAT4 rs7574865 TT基因型对叙利亚RA患者的ACPA阳性有潜在影响。然而，与HLA-DRB1共享表位等位基因等其他遗传因素相比，STAT4 rs7574865对RA发病和严重程度的影响较小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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