{"title":"Association Between <i>STAT4</i> rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.","authors":"Iman Tarakji, Wafa Habbal, Fawza Monem","doi":"10.2174/1874312901812010172","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>STAT4</i> rs7574865 polymorphism has been evidently associated with susceptibility to Rheumatoid Arthritis (RA) in European and Eastern Asian populations, whereas studies in other countries reported otherwise.</p><p><strong>Objective: </strong>We investigated the distribution of <i>STAT4</i> rs7574865 polymorphism in a group of Syrian RA patients.</p><p><strong>Methods: </strong>Eighty-one RA patients and forty healthy controls were enrolled and <i>STAT4</i> rs7574865 was genotyped by direct sequencing. RA patients were stratified according to Anti-Citrullinated Protein Antibodies (ACPA) status for analysis.</p><p><strong>Results: </strong>Minor T allele frequencies were 30.4%, 16.7%, and 23.8% in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively. No significant differences in <i>STAT4</i> rs7574865 allele/genotype frequencies were found between ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls (P>0.05).</p><p><strong>Conclusion: </strong><i>STAT4</i> rs7574865 TT genotype showed a potential impact on ACPA positivity in Syrian RA patients. However, <i>STAT4</i> rs7574865 effect on RA onset and severity is minor compared to other genetic factors such as <i>HLA-DRB1</i> shared epitope alleles.</p>","PeriodicalId":88179,"journal":{"name":"","volume":"12 ","pages":"172-178"},"PeriodicalIF":0.0,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210524/pdf/","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874312901812010172","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Background: STAT4 rs7574865 polymorphism has been evidently associated with susceptibility to Rheumatoid Arthritis (RA) in European and Eastern Asian populations, whereas studies in other countries reported otherwise.
Objective: We investigated the distribution of STAT4 rs7574865 polymorphism in a group of Syrian RA patients.
Methods: Eighty-one RA patients and forty healthy controls were enrolled and STAT4 rs7574865 was genotyped by direct sequencing. RA patients were stratified according to Anti-Citrullinated Protein Antibodies (ACPA) status for analysis.
Results: Minor T allele frequencies were 30.4%, 16.7%, and 23.8% in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively. No significant differences in STAT4 rs7574865 allele/genotype frequencies were found between ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls (P>0.05).
Conclusion: STAT4 rs7574865 TT genotype showed a potential impact on ACPA positivity in Syrian RA patients. However, STAT4 rs7574865 effect on RA onset and severity is minor compared to other genetic factors such as HLA-DRB1 shared epitope alleles.