Exploration of Adhesion Molecule Expression in Cardiac Muscle of Early Atherosclerosis Dyslipidemic Sprague Dawley Rats.

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2018-10-24 eCollection Date: 2018-01-01 DOI:10.2174/1874104501812010124

Titin A Wihastuti, Fitria N Aini, Nurul C Lutfiana, Teuku Heriansyah, Nafisatuz Zamrudah

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Abstract

Objective: This study is aimed to examine the expression of ICAM-1 and VCAM-1 in cardiac tissue of dyslipidemic Sprague Dawley rats.

Methods: Eight Sprague Dawley strain rats, with 150-200 gram body weight, were divided into two groups. The control group was fed a standard diet, the positive control group was fed a high-fat diet as our previous study for 8 weeks. The pattern of distribution of ICAM-1 and VCAM-1 in cardiac muscle cell was examined by immunofluorescence and observed with a confocal laser scanning microscope. Lipid profile was also examined at the end of the study.

Result: Independent t-test showed no differences in ICAM-1 and VCAM-1 expression in cardiac muscle of hypercholesterol-diet-fed Sprague Dawley rat compared to control.

Conclusion: The expression of ICAM-1 and VCAM-1 in cardiac muscle did not change after the onset of atherosclerosis.

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早期动脉粥样硬化血脂异常 Sprague Dawley 大鼠心肌中粘附分子表达的探索

研究目的本研究旨在检测血脂异常的 Sprague Dawley 大鼠心脏组织中 ICAM-1 和 VCAM-1 的表达：方法：将 8 只体重为 150-200 克的 Sprague Dawley 株大鼠分为两组。对照组饲喂标准饮食，阳性对照组饲喂高脂饮食（与我们之前的研究相同），为期 8 周。用免疫荧光法检测心肌细胞中 ICAM-1 和 VCAM-1 的分布模式，并用激光共聚焦扫描显微镜进行观察。研究结束时还检测了血脂谱：结果：独立t检验显示，与对照组相比，高胆固醇饮食喂养的Sprague Dawley大鼠心肌中ICAM-1和VCAM-1的表达没有差异：结论：动脉粥样硬化发生后，ICAM-1和VCAM-1在心肌中的表达没有变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

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0.00%

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