DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38.

IF 3.2 Q2 GENETICS & HEREDITY
Epigenetics Insights Pub Date : 2018-11-19 eCollection Date: 2018-01-01 DOI:10.1177/2516865718811117
Maud de Dieuleveult, Benoit Miotto
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引用次数: 12

Abstract

DNA methylation plays an essential role in the control of gene expression during early stages of development as well as in disease. Although many transcription factors are sensitive to this modification of the DNA, we still do not clearly understand how it contributes to the establishment of proper gene expression patterns. We discuss here the recent findings regarding the biological and molecular function(s) of the transcription factor ZBTB38 that binds methylated DNA sequences in vitro and in cells. We speculate how these findings may help understand the role of DNA methylation and DNA methylation-sensitive transcription factors in mammalian cells.

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DNA甲基化和染色质:甲基- cpg结合蛋白ZBTB38的作用。
DNA甲基化在发育早期和疾病阶段的基因表达控制中起着至关重要的作用。尽管许多转录因子对DNA的这种修饰很敏感,但我们仍然不清楚它如何有助于建立适当的基因表达模式。我们在此讨论了在体外和细胞中结合甲基化DNA序列的转录因子ZBTB38的生物学和分子功能的最新发现。我们推测这些发现可能有助于理解DNA甲基化和DNA甲基化敏感转录因子在哺乳动物细胞中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
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