A Survey of Infection in Allogenic Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia.

IF 0.3 Q4 TRANSPLANTATION
International Journal of Organ Transplantation Medicine Pub Date : 2018-01-01 Epub Date: 2018-08-01
S R Safayi, F Shahi, M Ghalamkari, M Mirzania, M Khatuni, F Hirmandi Niasar
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引用次数: 0

Abstract

Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially cure for acute myeloid leukemia (AML). Patients who undergone HSCT are at increased risk of infection due to impaired immunity.

Objective: To evaluate the rate of bacterial, viral and fungal infection and its relationship with 2-year overall survival of AML patients who had undergone HSCT.

Methods: This was a retrospective cross-sectional study of 49 patients who underwent allogenic bone marrow transplantation (BMT) from full-matched donors at BMT Center, Imam Khomeini Hospital Complex, Tehran, Iran, from 2006 to 2013. All autologous transplantations and promyelocytic leukemia (PML) transplantations were excluded.

Results: All patients, except for one, had fever for a mean of 7 days post-transplantation and received broad-spectrum antibiotic. The rate of severe sepsis was 6.1%. None of the patients developed fungal infection during admission. The rate of admission due to sepsis after discharge was 27% in the alive group (mean onset of 54 days), and 73% in the deceased group (mean onset of 52 days) (p<0.05). The most common site of infection was lung (70%). The rate of cytomegalovirus (CMV) antigenemia (positive PP65) was 20% during the 2-year period after HSCT.

Conclusion: The rate of infection was a negative prognostic factor for 2-year overall survival. The rate of CMV antigenemia is less than similar studies (51%), which could be due to full-matched donor-recipients requiring less immunosuppression.

Abstract Image

急性髓系白血病患者同种异体造血干细胞移植感染的调查。
背景:同种异体造血干细胞移植(HSCT)是治疗急性髓性白血病(AML)的潜在方法。由于免疫功能受损,接受造血干细胞移植的患者感染风险增加。目的:探讨急性髓系白血病患者行HSCT后的细菌、病毒和真菌感染率及其与2年总生存率的关系。方法:这是一项回顾性横断面研究,对2006年至2013年在伊朗德黑兰伊玛目霍梅尼医院BMT中心接受完全匹配供体同种异体骨髓移植(BMT)的49例患者进行了回顾性研究。排除所有自体移植和早幼粒细胞白血病(PML)移植。结果:除1例患者外,所有患者在移植后平均7天出现发热,并接受了广谱抗生素治疗。严重脓毒症发生率为6.1%。所有患者入院时均未发生真菌感染。活组患者出院后脓毒症住院率为27%(平均发病54天),死组患者出院后脓毒症住院率为73%(平均发病52天)。结论:感染发生率是影响患者2年总生存率的一个不利因素。巨细胞病毒抗原血症的发生率低于类似研究(51%),这可能是由于供体-受体完全匹配需要较少的免疫抑制。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊介绍: The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.
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