Recent advances of the Povarov reaction in medicinal chemistry

Q1 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Technologies Pub Date : 2018-11-01 DOI:10.1016/j.ddtec.2018.08.004

Ouldouz Ghashghaei , Carme Masdeu , Concepción Alonso , Francisco Palacios , Rodolfo Lavilla

引用次数: 48

Abstract

The Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity points. Hereby, we report the main features of this transformation and its uses in medicinal chemistry. Relevant examples of the impact of Povarov adducts in different therapeutic areas are provided.

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波瓦洛夫反应在药物化学中的最新进展

Povarov多组分反应是由苯胺、醛和活性烯烃缩合生成具有3个多样性点的四氢喹啉加合物。在此，我们报告了这种转化的主要特征及其在药物化学中的应用。提供了波瓦洛夫加合物在不同治疗领域的影响的相关实例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drug Discovery Today: Technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Discovery Today: Technologies compares different technological tools and techniques used from the discovery of new drug targets through to the launch of new medicines.