Combatting mucosal melanoma: recent advances and future perspectives.

IF 1 Q4 ONCOLOGY

Melanoma Management Pub Date : 2018-10-08 eCollection Date: 2018-09-01 DOI:10.2217/mmt-2018-0003

Helen Tyrrell, Miranda Payne

引用次数: 0

Abstract

Mucosal melanomas are a rare subtype of melanoma and are associated with a particularly poor prognosis. Due to the rarity of the diagnosis, and the pace with which the management of cutaneous melanoma has evolved over recent years, there is little good evidence to guide management and evidence-based clinical guidelines are still in development in the UK. In this review we provide an overview of the management of mucosal melanoma, highlighting the critical differences between cutaneous and mucosal melanomas, before examining recent advances in the systemic treatment of this disease and likely future directions.

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抗击粘膜黑色素瘤：最新进展与未来展望。

粘膜黑色素瘤是黑色素瘤的一种罕见亚型，预后特别差。由于这一诊断的罕见性，以及近年来皮肤黑色素瘤治疗方法的发展速度，目前几乎没有可靠的证据来指导治疗，英国的循证临床指南仍在制定中。在这篇综述中，我们将概述粘膜黑色素瘤的治疗方法，强调皮肤黑色素瘤和粘膜黑色素瘤之间的重要区别，然后再探讨这种疾病的系统治疗方面的最新进展以及未来可能的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.