[Liver Fibrosis is Associated with Loss of Skeletal Muscle Mass in Community-Dwelling Older Adults with No History of Liver Diseases].

Q3 Medicine
Shuhei Ohnishi, Nobuyuki Miyai, Miyoko Utsumi, Kanae Mure, Tatsuya Takeshita, Mitsuru Shiba, Mikio Arita
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引用次数: 2

Abstract

Objectives: In this study, we aimed to examine the possible association between liver fibrosis and loss of skeletal muscle mass (SM) in community-dwelling older adults with no history of liver diseases.

Methods: A total of 2,028 older adults (mean age, 69.8 ± 5.2 years) who had not received any treatment for liver diseases and had participated in a comprehensive health survey for community residents in Wakayama, Japan were included in this study. We carried out bioelectrical impedance analysis to estimate the SM of the whole body including the arms, legs, and trunk of the subjects. Liver fibrosis was evaluated by calculating the Fib4 index based on the subject's age, AST level, ALT level, and platelet counts.

Results: The subjects were divided into three groups according to cutoff values of the Fib4 index (low: <1.30, medium: 1.30-2.66, high: ≥2.67). The SM index (kg/m2) was the lowest among subjects in the high-Fib4-index category, followed by the medium- and low-Fib4-index categories. This dose-response reduction in the SM index was more pronounced among individuals with lower blood albumin level (low nutrition) and in those with more sedentary behavior (physical inactivity). Among the selected 262 subjects who underwent SM measurement twice with an interval of 3 years, the subjects with a high Fib4 index showed greater reduction in the SM index than those with medium and low Fib4 indices. Multiple regression analysis revealed that the Fib4 index was significantly associated with the SM index, independent of age, sex, albumin level, sedentary behavior, diabetes mellitus, alcohol intake, and smoking status.

Conclusions: The present findings suggest that the potential progression of liver fibrosis is associated with the excessive loss of SM among apparently healthy older adults without any treatment for liver diseases.

[肝纤维化与无肝病史的社区老年人骨骼肌质量损失相关]。
目的:在本研究中,我们旨在研究无肝病史的社区居住老年人肝纤维化与骨骼肌质量(SM)损失之间的可能关联。方法:研究对象为参加日本和歌山社区居民综合健康调查的未接受任何肝脏疾病治疗的2028名老年人(平均69.8±5.2岁)。我们进行了生物电阻抗分析来估计整个身体的SM,包括受试者的手臂、腿和躯干。根据受试者的年龄、AST水平、ALT水平和血小板计数计算Fib4指数来评估肝纤维化。结果:按照Fib4指数截断值将受试者分为三组(低:2),高Fib4指数组受试者最低,其次是中、低Fib4指数组。在血白蛋白水平较低(低营养)和久坐行为较多(缺乏身体活动)的个体中,SM指数的剂量反应降低更为明显。在选取的262名受试者中,间隔3年进行两次SM测量,高Fib4指数的受试者SM指数下降幅度大于中、低Fib4指数的受试者。多元回归分析显示,Fib4指数与SM指数显著相关,与年龄、性别、白蛋白水平、久坐行为、糖尿病、饮酒和吸烟状况无关。结论:目前的研究结果表明,在未接受任何肝脏疾病治疗的表面健康老年人中,肝纤维化的潜在进展与SM的过度丧失有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Japanese Journal of Hygiene
Japanese Journal of Hygiene Medicine-Medicine (all)
CiteScore
0.90
自引率
0.00%
发文量
7
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