Untreated chronic lymphocytic leukemia in Lebanese patients: an observational study using standard karyotyping and FISH.

International Journal of Hematologic Oncology Pub Date : 2017-12-01 Epub Date: 2017-12-21 DOI:10.2217/ijh-2017-0019

Elie El Rassy, Alain Chebly, Rima Korban, Warde Semaan, Ziad Bakouny, Tarek Assi, Hampig Raphael Kourie, Fadi El Karak, Eliane Chouery, Joseph Kattan

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引用次数: 0

Abstract

Aim: We aimed to understand the biology of chronic lymphocytic leukemia (CLL) patients in Lebanon.

Materials & methods: We applied conventional cytogenetic and FISH studies on Lebanese patients diagnosed with CLL and undergoing a watch and wait approach.

Results: Our study disclosed 53.6% of patients with aberrant karyotypes among which 26.7% were complex karyotypes. Genetic aberrations included del(13q14) 46.4%, 14q32 translocation in 25%, trisomy 12 in 14.3%, del(17p13) and del(11q22) in 7.1% each. The deletion of 6q21/6q23 was not found in any of our patients.

Conclusion: The higher prevalence of del(13q14) as a sole abnormality could be the primary event in inducing CLL. The del(17p13) and del(11q22) followed as potential drivers for progression in CLL patients with a watch and wait approach.

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黎巴嫩患者中未经治疗的慢性淋巴细胞白血病：使用标准核型和 FISH 的观察性研究。

目的：我们旨在了解黎巴嫩慢性淋巴细胞白血病（CLL）患者的生物学特性：我们对确诊为慢性淋巴细胞白血病并接受观察和等待治疗的黎巴嫩患者进行了常规细胞遗传学和 FISH 研究：我们的研究发现，53.6%的患者核型异常，其中26.7%为复杂核型。基因畸变包括 del(13q14) 46.4%、14q32 易位 25%、12 三体 14.3%、del(17p13) 和 del(11q22) 各 7.1%。我们的患者中没有发现 6q21/6q23 缺失：结论：del(13q14)作为唯一异常的发生率较高，可能是诱发CLL的主要原因。Del(17p13)和Del(11q22)是导致CLL患者病情恶化的潜在因素，应采取观察和等待的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hematologic Oncology

自引率

0.00%

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审稿时长

13 weeks

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