The Role of Liver-Directed Therapy in Metastatic Colorectal Cancer.

Q3 Medicine

Current Colorectal Cancer Reports Pub Date : 2018-01-01 Epub Date: 2018-09-13 DOI:10.1007/s11888-018-0409-6

Hon Lyn Tan, Matilda Lee, Balamurugan A Vellayappan, Wee Thong Neo, Wei Peng Yong

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引用次数: 9

Abstract

Purpose of review: Colorectal cancer liver metastasis is a major clinical problem, and surgical resection is the only potentially curative treatment. We seek to discuss various liver-directed therapy modalities and explore their roles in the evolving realm of treatment strategies for metastatic colorectal cancer.

Recent findings: Clinical outcomes for patients with colorectal cancer liver metastases have improved as more patients undergo potentially curative resection and as the armamentarium of systemic treatment and liver-directed therapies continues to expand. Liver-directed therapies have been developed as adjuncts to improve resectability, employed in the adjuvant setting to potentially reduce local recurrence rates, and utilized in the palliative setting with the aim to improve overall survival.

Summary: Ongoing research is expected to validate the role of these evolving therapeutic options, and determine how best to sequence and when to apply these therapies.

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肝定向治疗在转移性结直肠癌中的作用。

综述目的:结直肠癌肝转移是一个重大的临床问题，手术切除是唯一可能治愈的治疗方法。我们试图讨论各种肝脏导向的治疗方式，并探讨其在转移性结直肠癌治疗策略不断发展的领域中的作用。最近的研究发现:随着更多的患者接受可能治愈的切除手术，以及全身治疗和肝脏定向治疗的范围不断扩大，结直肠癌肝转移患者的临床结果有所改善。肝脏定向治疗已经发展成为提高可切除性的辅助治疗，用于辅助治疗以潜在地降低局部复发率，并用于姑息治疗以提高总生存率。总结:正在进行的研究有望验证这些不断发展的治疗选择的作用，并确定如何最好地排序以及何时应用这些治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Colorectal Cancer Reports ONCOLOGY-

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期刊介绍： This journal aims to review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of colorectal cancer. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those with the disease. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and emerging therapeutic approaches and the molecular basis of disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.