[Environmental Chemical Exposure and Its Effects on Infants' Reproductive Hormones].

Q3 Medicine
Atsuko Araki, Sachiko Itoh, Chihiro Miyashita, Machiko Minatoya, Reiko Kishi
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引用次数: 0

Abstract

In recent years, the birthrate has been continuously declining in Japan. The main causes of the decline are social factors. On the other hand, there is increasing evidence that many environmental chemicals show endocrine disrupting properties. Thus, we hypothesized that exposure to these chemicals would also be a causal for the fertility crisis. In this review, we examined current evidence that focused on environmental chemical exposure in utero and its association with reproductive hormones in children. We have included the findings from a prospective birth cohorts, the Hokkaido Study on Environment and Children's Health Sapporo cohort. According to the literature, environmental chemical levels in utero, such as polychlorinated biphenyl, dioxins, perfluorinated chemical substances, phthalates, and bisphenol A were somewhat associated with the levels of reproductive hormones, such as testosterone, estradiol, progesterone, inhibin B, and insulin-like factor-3 in cord blood, in early childhood and adolescence. The literature also suggests the association between exposure to these chemicals and brain-sexual differentiation or the anogenital distance, which suggests the disruption of androgen shower during the developmental stage in the fetal period. There are still knowledge gaps on whether these hormones at an early stage affect the pubertal development and reproductive functions in later life. In addition, alternative chemicals are produced after banning one type. The health effects of alternative chemicals should be evaluated. Effects of exposure to a mixture of the chemicals should also be examined in future studies. In conclusion, the prevention of environmental chemical hazards in relation to human reproductive function is important. It would be one of the countermeasures to the falling birthrate caused by fertility issues.

环境化学物质暴露及其对婴儿生殖激素的影响
近年来,日本的出生率一直在持续下降。下降的主要原因是社会因素。另一方面,越来越多的证据表明,许多环境化学物质具有干扰内分泌的特性。因此,我们假设接触这些化学物质也会导致生育危机。在这篇综述中,我们研究了目前的证据,主要集中在子宫内环境化学暴露及其与儿童生殖激素的关系。我们纳入了一项前瞻性出生队列的研究结果,即北海道环境与儿童健康研究札幌队列。根据文献,子宫内的环境化学物质水平,如多氯联苯、二恶英、全氟化学物质、邻苯二甲酸盐和双酚A,与幼儿和青少年脐带血中的生殖激素水平,如睾酮、雌二醇、黄体酮、抑制素B和胰岛素样因子-3的水平有一定的相关性。文献还表明,接触这些化学物质与大脑-性别分化或肛门-生殖器距离之间存在关联,这表明在胎儿时期发育阶段雄激素阵雨的中断。早期的这些激素是否会影响青春期发育和后期的生殖功能,目前还存在知识空白。另外,在禁用一种化学物质后,还会生产替代化学物质。应评估替代化学品对健康的影响。在未来的研究中也应检查接触这些化学物质混合物的影响。总之,预防与人类生殖功能有关的环境化学品危害是重要的。这将是解决由生育问题引起的出生率下降的对策之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Japanese Journal of Hygiene
Japanese Journal of Hygiene Medicine-Medicine (all)
CiteScore
0.90
自引率
0.00%
发文量
7
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