[Study on Quality Evaluation of Ophiopogonis Radix in Sichuan].

中药材 Pub Date : 2016-08-01

Fa-ming Wu, Hai-yan Yang, Rui-shan Yang, Min Li, Xiao-hong Bao, Juan Zhou

{"title":"[Study on Quality Evaluation of Ophiopogonis Radix in Sichuan].","authors":"Fa-ming Wu, Hai-yan Yang, Rui-shan Yang, Min Li, Xiao-hong Bao, Juan Zhou","doi":"","DOIUrl":null,"url":null,"abstract":"Objective: To evaluate the quality of Ophiopogonis Radix from produce area, circulation link and clinical application in Sichuan, and to provide the theoretical basis for the quality control of Ophiopogonis Radix in Sichuan.Methods: 105 samples were collected from different produce area, market, factory of decoction pieces, drugstore in Sichuan. The content of moisture,total ash, extractum, total saponin, heavy metal, harmful element, pesticide residues, sulfur dioxide were measured by the methods which recorded in Chinese pharmacopoeia. The content of ophiopogonin D, methylophiopogonanone A, methylophiopogonanone B were measured by HPLC.Results: The content of moisture, total ash, extractum, total saponin in 105 samples Ophiopogonis Radix in Sichuan were at 5. 7%~ 17. 9%,0. 9% ~ 3. 4%,68. 7% ~ 95. 1%,0. 12% ~ 0. 57%,respectively. Over standard rate of sulfur dioxide was 23. 81%. The content of heavy metal and harmful element was conform to the limitation requirement of Chinese pharmacopoeia. Three kinds of organic pesticide had not been checked out. The content of ophiopogonin D, methylophiopogonanone A,methylophiopogonanone B were at 0. 04~ 0. 30 mg/kg,0. 0170 ~ 0. 0837 mg/kg,0. 0049 ~ 0. 0370 mg/kg, respectively.Conclusion: The quality of 105 samples are up to the requirement with the provisions of the Chinese pharmacopoeia. Actually,the mandatory standard was not perfect, especially lack of standard in security. It is suggested that strengthening supervision of sulfur dioxide and paclobutrazol residual according to the actual situation for ensuring the safe and effective of Ophiopogonis Radix in clinical application.","PeriodicalId":15312,"journal":{"name":"中药材","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中药材","FirstCategoryId":"3","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To evaluate the quality of Ophiopogonis Radix from produce area, circulation link and clinical application in Sichuan, and to provide the theoretical basis for the quality control of Ophiopogonis Radix in Sichuan.

Methods: 105 samples were collected from different produce area, market, factory of decoction pieces, drugstore in Sichuan. The content of moisture,total ash, extractum, total saponin, heavy metal, harmful element, pesticide residues, sulfur dioxide were measured by the methods which recorded in Chinese pharmacopoeia. The content of ophiopogonin D, methylophiopogonanone A, methylophiopogonanone B were measured by HPLC.

Results: The content of moisture, total ash, extractum, total saponin in 105 samples Ophiopogonis Radix in Sichuan were at 5. 7%~ 17. 9%,0. 9% ~ 3. 4%,68. 7% ~ 95. 1%,0. 12% ~ 0. 57%,respectively. Over standard rate of sulfur dioxide was 23. 81%. The content of heavy metal and harmful element was conform to the limitation requirement of Chinese pharmacopoeia. Three kinds of organic pesticide had not been checked out. The content of ophiopogonin D, methylophiopogonanone A,methylophiopogonanone B were at 0. 04~ 0. 30 mg/kg,0. 0170 ~ 0. 0837 mg/kg,0. 0049 ~ 0. 0370 mg/kg, respectively.

Conclusion: The quality of 105 samples are up to the requirement with the provisions of the Chinese pharmacopoeia. Actually,the mandatory standard was not perfect, especially lack of standard in security. It is suggested that strengthening supervision of sulfur dioxide and paclobutrazol residual according to the actual situation for ensuring the safe and effective of Ophiopogonis Radix in clinical application.

本刊更多论文

[四川麦冬药材质量评价研究]。

目的:对四川省麦冬产地、流通环节及临床应用的质量进行评价，为四川省麦冬药材的质量控制提供理论依据。方法:从四川省不同产地、市场、饮片厂、药店等单位采集样品105份。水分、总灰分、提取物、总皂苷、重金属、有害元素、农药残留、二氧化硫含量采用中国药典规定的方法测定。采用高效液相色谱法测定麦冬皂苷D、甲基麦冬皂酮A、甲基麦冬皂酮B的含量。结果:105份四川麦冬样品的水分、总灰分、浸出物、总皂苷含量均为5。7% ~ 17。9%, 0。9% ~ 3%。4%, 68。7% ~ 95。1%, 0。12% ~ 0。57%,分别。二氧化硫超标率是23。81%。重金属和有害元素的含量符合《中国药典》的限量要求。三种有机农药未检出。麦冬皂苷D、甲基麦冬皂苷A、甲基麦冬皂苷B含量均为0。04 ~ 0。30毫克/公斤,0。0170 ~ 0。0837毫克/公斤,0。0049 ~ 0。分别为0370 mg/kg。结论:105份样品的质量均符合《中国药典》的要求。实际上，我国的强制性标准并不完善，尤其是在安全保障方面的标准缺失。建议根据实际情况加强二氧化硫和多效唑残留量的监管，确保麦冬在临床应用中的安全有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中药材

自引率

0.00%

发文量

11364

期刊介绍： "Chinese Materia Medica" magazine was founded in 1978. It is a national-level academic journal of Chinese medicine science and technology approved by the State Science and Technology Commission and the Press and Publication Administration for public distribution at home and abroad. It is sponsored by the Chinese Materia Medica Information Center of the State Food and Drug Administration and is publicly distributed at home and abroad. It mainly reports on new technologies, new methods and new achievements in the production, scientific research and business management of Chinese medicine, and serves to promote the production and scientific and technological development of Chinese medicine, improve the output and quality of Chinese medicine, improve business management, and prosper the Chinese medicine industry.