Neuroenergetics of traumatic brain injury.

Q3 Medicine
Concussion Pub Date : 2015-09-22 eCollection Date: 2016-03-01 DOI:10.2217/cnc.15.9
Kate Karelina, Zachary M Weil
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引用次数: 7

Abstract

A subset of traumatic brain injury (TBI) patients exhibit cognitive deficits later in life which may be due to the underlying pathology associated with Alzheimer's disease (AD) or chronic traumatic encephalopathy. The similarities between chronic traumatic encephalopathy and AD merit investigation of potentially similar mechanisms underlying the two diseases. Experimental and clinical studies of AD brains have revealed that insulin resistance links metabolic dysfunction to the neurodegeneration and cognitive deficits associated with AD. Recent work in experimental TBI has established that recovery is dependent on the return of normal brain metabolism and mounting evidence for a role of brain insulin in regulating central metabolism suggests that TBI, like AD, results in central insulin resistance. Here, we review the converging evidence from AD, TBI and diabetes research linking insulin insensitivity to neurodegeneration.

Abstract Image

外伤性脑损伤的神经能量学。
一部分创伤性脑损伤(TBI)患者在以后的生活中表现出认知缺陷,这可能是由于与阿尔茨海默病(AD)或慢性创伤性脑病相关的潜在病理所致。慢性创伤性脑病和AD之间的相似之处值得研究这两种疾病潜在的相似机制。阿尔茨海默病大脑的实验和临床研究表明,胰岛素抵抗将代谢功能障碍与阿尔茨海默病相关的神经变性和认知缺陷联系起来。最近在实验性脑损伤方面的研究表明,脑损伤的恢复依赖于正常脑代谢的恢复。越来越多的证据表明,脑胰岛素在调节中枢代谢中的作用表明,脑损伤与阿尔茨海默病一样,会导致中枢胰岛素抵抗。在这里,我们回顾了来自AD、TBI和糖尿病研究的证据,这些证据表明胰岛素不敏感与神经变性有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Concussion
Concussion Medicine-Neurology (clinical)
CiteScore
2.70
自引率
0.00%
发文量
2
审稿时长
12 weeks
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