Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo.

Q2 Medicine
BMC Hematology Pub Date : 2018-09-06 eCollection Date: 2018-01-01 DOI:10.1186/s12878-018-0118-z
Olivier Mukuku, Joseph K Sungu, Augustin Mulangu Mutombo, Paul Makan Mawaw, Michel Ntetani Aloni, Stanislas Okitotsho Wembonyama, Oscar Numbi Luboya
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引用次数: 7

Abstract

Background: Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular and extracellular enzymes. These enzymes requires micronutrient for complete activity. Information on micronutrients such as manganese, cobalt and copper in SCA population was poorly documented in the literature.

Methods: Plasma copper, manganese, cobalt and albumin concentrations determined by atomic absorption spectrophotometry were compared between two groups of children: 76 with SCA (Hb-SS) and 76 without SCA (controls). This study was conducted in the Muhona Hospital of Kasumbalesa, which is situated in a rural and low in resources.

Results: The mean age was 10.0 years (SD = 5.4) in SCA children and 9.2 years (SD = 4.7) in the control group. The levels of cobalt, manganese, copper and albumin were not different between the two groups (p > 0.05).

Conclusion: In our study, albumin, manganese, cobalt and copper values did not differ between SCA children in steady state and Hb-AA children. The lack of differences in plasma elemental concentrations between the two groups in context of increased demands in the SCA group, may represent adequate compensatory intake or elemental dyshomeostasis in the SCA group.

Abstract Image

刚果民主共和国卡松巴莱萨镰状细胞性贫血患儿白蛋白、铜、锰和钴水平。
背景:镰状细胞性贫血(SCA)的特点是高水平的氧化应激标志物和低水平的抗氧化能力。针对活性氧有害影响的抗氧化防御机制需要细胞和细胞外酶。这些酶需要微量营养素才能完全发挥活性。文献中关于SCA人群中微量营养素如锰、钴和铜的资料很少。方法:比较原子吸收分光光度法测定的两组患儿血浆铜、锰、钴和白蛋白浓度:76例SCA患儿(Hb-SS)和76例非SCA患儿(对照组)。这项研究是在卡松巴莱萨的Muhona医院进行的,该医院位于农村,资源匮乏。结果:SCA患儿平均年龄为10.0岁(SD = 5.4),对照组平均年龄为9.2岁(SD = 4.7)。两组血清钴、锰、铜、白蛋白水平差异无统计学意义(p > 0.05)。结论:在我们的研究中,稳定状态的SCA儿童和Hb-AA儿童的白蛋白、锰、钴和铜值没有差异。在SCA组需要量增加的情况下,两组血浆元素浓度没有差异,可能代表SCA组有足够的代偿性摄入或元素失衡。
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来源期刊
BMC Hematology
BMC Hematology Medicine-Hematology
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: BMC Hematology is an open access, peer-reviewed journal that considers articles on basic, experimental and clinical research related to hematology. The journal welcomes submissions on non-malignant and malignant hematological diseases, hemostasis and thrombosis, hematopoiesis, stem cells and transplantation.
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