Microbial Infections and Antimicrobial Resistance in Nepal: Current Trends and Recommendations.

Q3 Immunology and Microbiology

Open Microbiology Journal Pub Date : 2018-07-31 eCollection Date: 2018-01-01 DOI:10.2174/1874285801812010230

Ram H Dahal, Dhiraj K Chaudhary

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引用次数: 46

Abstract

Antimicrobial resistance is a life threatening challenges to the world. Most of the well-known antibiotics are currently ineffective to several microbial diseases. Ampicillin, metronidazole, amoxicillin, cotrimoxazole, chloramphenicol, ciprofloxacin, nalidixic acid, gentamicin, and ceftazidime are common antibiotics whose resistance pattern has been elevated in recent years. The rise and dissemination of resistant bacteria has contributed in increasing cases of antimicrobial resistance. Multi-drug Resistant (MDR) organism such as Staphylococcus aureus, Pseudomionas aeruginosa, Escherchia coli, and Mycobacterium tuberculosis are principal problems for public health and stakeholders. Globally, issues of antimicrobial resistance are major concern. In the context of Nepal, insufficient surveillance system, lack of appropriate policy, and poor publications regarding the use of antibiotics and its resistance pattern has misled to depict exact scenario of antimicrobial resistance. This mini-review presents current trends of antibiotic use and its resistance pattern in Nepal. In addition, global progression of antibiotic discovery and its resistance has been covered as well. Furthermore, use of antibiotics and possible ways on improvement of effectiveness have been discussed.

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尼泊尔的微生物感染和抗菌素耐药性:当前趋势和建议。

抗菌素耐药性是全世界面临的威胁生命的挑战。大多数已知的抗生素目前对几种微生物疾病无效。氨苄西林、甲硝唑、阿莫西林、复方新诺明、氯霉素、环丙沙星、那利地酸、庆大霉素和头孢他啶是近年来耐药性升高的常见抗生素。耐药细菌的增加和传播导致了抗菌素耐药性病例的增加。耐多药(MDR)生物，如金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌和结核分枝杆菌，是公共卫生和利益相关者面临的主要问题。在全球范围内，抗微生物药物耐药性问题是主要问题。在尼泊尔的情况下，关于抗生素使用及其耐药模式的监测系统不足、缺乏适当的政策以及不良出版物误导了对抗菌素耐药情况的准确描述。这篇小型综述介绍了尼泊尔目前抗生素使用的趋势及其耐药模式。此外，还介绍了抗生素的发现及其耐药性的全球进展。此外，还讨论了抗生素的使用和提高疗效的可能途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Microbiology Journal Immunology and Microbiology-Immunology and Microbiology (all)

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Open Microbiology Journal is a peer-reviewed open access journal which publishes research articles, reviews/mini-reviews, case studies, guest edited thematic issues and short communications/letters covering theoretical and practical aspects of Microbial systematics, evolutionary microbiology, immunology, virology, parasitology , bacteriology, mycology, phycology, protozoology, microbial ecology, molecular biology, microbial physiology, biochemistry, microbial pathogenesis, host-microbe interaction, systems microbiology, synthetic microbiology, bioinformatics. The Open Microbiology Journal , a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and freely available to researchers worldwide.