[CHRONIC UNPREDICTABLE STRESS OF PREGNANT RATS AND HEALTH OUTCOMES OF THEIR OFFSPRING].

Abstract

It was established that chronic unpredictable stress, which was reproduced by repeated exposure of adverse factors on the pregnant rats (food deprivations during one day, immobilization in the water of room temperature and contact with Felis excrements) results in the stable and sex-specific offspring's behavioural changes in the «open field» test, disorders of motor and coordinator functions and the increased sensitivity to pain at the age of both 1 and 3 months. Male and female rats, which were exposed to the prenatal stress, demonstrate elevated blood pressure. Enhanced lipoperoxidation in the blood serum of male rats after prenatal stress was indicated. Thus, prenatal stress leads to the stable alteration of the reactivity, which may favour persistent social maladjustment and the development of different pathologies.