[CHANGES OF THE OXIDATIVE STATUS, MITOCHONDRIAL FUNCTION, BLOOD PRESSURE AND INDICATORS OF HEMOSTASIS IN STRESSED ANIMALS AND IN THE CONDITIONS OF NO-SYNTHASE BLOCKADE].
V N Perfilova, T A Popova, I I Prokofiev, A V Borisov, G I Zaypullaev, E A Muzyko, M V Kustova, I N Tuyrenkov
{"title":"[CHANGES OF THE OXIDATIVE STATUS, MITOCHONDRIAL FUNCTION, BLOOD PRESSURE AND INDICATORS OF HEMOSTASIS IN STRESSED ANIMALS AND IN THE CONDITIONS OF NO-SYNTHASE BLOCKADE].","authors":"V N Perfilova, T A Popova, I I Prokofiev, A V Borisov, G I Zaypullaev, E A Muzyko, M V Kustova, I N Tuyrenkov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Changes in the metabolism of female rats hanging by cervical dorsal skin fold within 24 hours were examined. It was found that stress exposure results in an increase of the concentration of the final nitric oxide metabolites in the blood serum and homogenates of the heart and brain of animals, intensification of processes peroxidation lipids and mitochondrial dysfunction in these organs. Thus increase of mean arterial blood pressure by 18.9 % from baseline and violation of platelet and plasma components of hemostasis. Inhibitor of neuronal NO-synthase 7-nitroindazole in the dose of 50 mg/kg aggravates of the studied parameters changes. Administration of an animal selective inhibitor of inducible NOS aminoguanidine (50 mg / kg) contributes to limiting the damaging effects of stress reaction.</p>","PeriodicalId":21358,"journal":{"name":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"102 7","pages":"833-46"},"PeriodicalIF":0.0000,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Changes in the metabolism of female rats hanging by cervical dorsal skin fold within 24 hours were examined. It was found that stress exposure results in an increase of the concentration of the final nitric oxide metabolites in the blood serum and homogenates of the heart and brain of animals, intensification of processes peroxidation lipids and mitochondrial dysfunction in these organs. Thus increase of mean arterial blood pressure by 18.9 % from baseline and violation of platelet and plasma components of hemostasis. Inhibitor of neuronal NO-synthase 7-nitroindazole in the dose of 50 mg/kg aggravates of the studied parameters changes. Administration of an animal selective inhibitor of inducible NOS aminoguanidine (50 mg / kg) contributes to limiting the damaging effects of stress reaction.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
