[THE DAMAGING EFFECTS AT AN EARLY AGE ALTER PAIN SENSITIVITY IN ADULT FEMALE RATS, CORRECTION WITH BUSPIRONE].

Abstract

Most studies on the damaging effects of pain and stress impacts in the neonatal period of development on pain sensitivity were performed on individuals of the male sex. In the present study, we investigated the influence of inflammatory pain and/or stress of isolation from the mother in newborn female rats to pain sensitivity when they reached adulthood; an attempt was undertaken to correct identified deviations using 5-HT1A-receptor agonist buspirone. Adult females exposed to early pain displayed increased hypoalgesia in the hot plate test and rats subjected to stress of isolation from the mother showed increased hyperalgesia in the formalin test. The pain and subsequent isolation from the mother did not change pain sensitivity in the adult females. The chronic injection of buspirone from 25 th to 39 th day of life to females subjected to inflammatory pain and isolation from the mother in the neonatal period caused the normalization of pain sensitivity when they reached adulthood. It is found that the prepubertal period is a critical period for the correction of deviations caused by damaging impacts in neonatal rata in the functional activity of the nociceptive system.